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神経膠腫細胞の重粒子線照射効果関連レドックス遺伝子群の解析
https://repo.qst.go.jp/records/62678
https://repo.qst.go.jp/records/62678ed425e63-6053-4510-9809-189f23c9d683
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-08-18 | |||||
| タイトル | ||||||
| タイトル | 神経膠腫細胞の重粒子線照射効果関連レドックス遺伝子群の解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
盛武, 敬
× 盛武, 敬× 田草川, 光子× 中渡, 美也子× 今留, 香織× 酒井, 美奈子× 中村, 悦子× 柳澤, 充× 安西, 和紀× 岩川, 眞由美× 今井, 高志× 盛武 敬× 田草川 光子× 中渡 美也子× 今留 香織× 酒井 美奈子× 中村 悦子× 柳澤 充× 安西 和紀× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose --- In order to clarify the molecular changes in response to high LET carbon ion irradiation in human glioblastoma cell lines. Materials and methods --- For evaluating the cell survival to X-ray and Carbon ion beams, colony-formation assays were performed in 11 glioblastoma and 2 fibroblast cell lines. In addition, 1.0 uM of 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) , which is rather stable radical, was added to MEM suspended with 7.5x106 cells/ml of each cells. Then, the decay of its electron spin resonance (ESR) was measured during 120 min using ESR spectrometer. Also, to elucidate the molecular response to irradiation, the total RNA was purified from those cells at 1 h, 3 h and 24 h after 2 Gy of exposure with X-ray and carbon ion beams. Results --- The sensitivity to X-ray varied widely in 11 glioblastoma cell lines. On the other hand, the survival curves for carbon ion irradiation showed little difference in sensitivity among them. The decay rates of Tempol signal were also varied among cell limes. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
