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Tracer kinetic modeling of [11C]AFM, a new PET imaging agent for the serotonin transporter

https://repo.qst.go.jp/records/62584
https://repo.qst.go.jp/records/62584
2e7e559f-d5db-46c3-af7b-1e95b6d9ec0f
Item type 会議発表用資料 / Presentation(1)
公開日 2008-06-23
タイトル
タイトル Tracer kinetic modeling of [11C]AFM, a new PET imaging agent for the serotonin transporter
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Naganawa, Mika

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WEKO 618241

Naganawa, Mika

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et.al

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WEKO 618242

et.al

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長縄 美香

× 長縄 美香

WEKO 618243

en 長縄 美香

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抄録
内容記述タイプ Abstract
内容記述 Objectives: [11C]AFM is a new radioligand for the serotonin transporter which showed higher specific binding than [11C]DASB in nonhuman primate studies. The aim of this study was to determine an appropriate kinetic model to quantify [11C]AFM binding in humans.
Methods: Four healthy subjects were involved in a test-retest protocol. Dynamic PET data were acquired for 120 min with an HRRT scanner. Arterial blood sampling and metabolite analysis were performed. A 1-exponential (1e), 2-exponential (2e), and Hill function were fitted to the parent fraction data. Regional time-activity curves (TACs) were obtained and kinetic analysis was performed using one-tissue (1T) or two-tissue (2T) models, and Logan graphical analysis (LGA).
Results: Metabolism of AFM was rapid with % parent of 31 plusminus 6.0 and 8.1 plusminus 4.0 at 30 and 90 min, respectively. The 2T model resulted in nonconvergence or unstable estimates. For the 1e and Hill models, means of residuals were far from zero compared with the 2e model. The 1T model with 2e metabolite fitting described the data very well in ROIs with high VT values. Moderate lack of fit was seen in ROIs with low VT in 3/8 scans. VT ranged from 6.5 plusminus 1.0 (cerebellum) to 23.9 plusminus 3.7 (thalamus), with K1 values of 0.33 to 0.43 mL/min/mL. LGA estimates were in excellent agreement with 1T: VT(LGA) = 0.94 VT(1T) + 0.78 (r2=0.99).
Conclusions: The 1T model well describes the kinetics of [11C]AFM in most cases. The lack of fit in the remaining cases may be due to uncertainties in the metabolite measurement, and suggest that the ultimate development of a reference region approach is desirable.
Research Support: NIMH (MH066624) and Grants-in-Aid for Scientific Research of JSPS (18-6916)
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 2008 SNM Annual Meeting
発表年月日
日付 2008-06-18
日付タイプ Issued
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