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Carbon ion radiotherapy for skull base and paracervical chordomas
https://repo.qst.go.jp/records/62549
https://repo.qst.go.jp/records/62549b58f724b-790c-47ed-a638-2ed1453de594
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-27 | |||||
| タイトル | ||||||
| タイトル | Carbon ion radiotherapy for skull base and paracervical chordomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasegawa, Azusa
× Hasegawa, Azusa× Mizoe, Junetsu× Tsujii, Hirohiko× 長谷川 安都佐× 溝江 純悦× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To estimate the toxicity and efficacy of carbon ion radiotherapy for skull base and paracervical chordomas. Materials and Methods: Between April 1997 and August 2007, a total of 46 patients with skull base or paracervical tumors were treated with carbon ion radiotherapy for the phase I/II or phase II clinical trials. The phase I/II dose escalation trial was performed up to the fourth-stage dose level (48 GyE, 52.8 GyE, 57.6 GyE and 60.8 GyE). A total carbon ion dose was delivered in 16 fractions over four weeks. From April 2004, a phase II clinical trial was initiated under the Highly Advanced Medical Technology scheme with an irradiation schedule of 60.8 GyE in 16 fractions over four weeks. Twenty-nine patients with chordoma were enrolled in these studies and analyzed. Results: The 29 patients consisting of 12 males and 17 females, their age range was from 16 to 76, with a median age of 47 years. Median follow-up time was 44 months (range, 8-112 months). At the time of analysis, there was no evidence of any serious acute or late reactions. A late grade 2 brain reaction was detected in 1 patient irradiated with 60.8 GyE, but no other adverse reactions were discovered. The tumor effect remains almost stable disease (SD) within six months after carbon ion radiotherapy, and there have been in most cases no changes in the tumor size for a long time. The 29 chordoma patients were divided into two groups; a low-dose group (n=10) irradiated with doses ranging from 48 to 57.8 GyE and a high-dose group (n=19) irradiated with a 60.8 GyE. The five-year local control rates were 60% for the low-dose group and 91% for the high-dose group. One of 19 patients irradiated with 60.8 GyE developed marginal failure 29 months after. The five-year overall survival rates were 89% for the low-dose group and 94% for the high-dose group. One patient of the high dose group died because of hepatic failure. Conclusions: Carbon ion radiotherapy compared with photon and/or proton radiotherapy will deliver high local control rates with low toxicity to the surrounding normal tissues. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG 47 Scientific Session | |||||
| 発表年月日 | ||||||
| 日付 | 2008-05-24 | |||||
| 日付タイプ | Issued | |||||
