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Functional deficits in the extrastriate body area in schizophrenia
https://repo.qst.go.jp/records/62544
https://repo.qst.go.jp/records/62544241b6b04-edf4-4ab1-a830-8a1ee4ffc3ea
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2008-05-22 | |||||
タイトル | ||||||
タイトル | Functional deficits in the extrastriate body area in schizophrenia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahashi, Hidehiko
× Takahashi, Hidehiko× 高橋 英彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Exercise and sports are increasingly being implemented in the management of schizophrenia. However, individuals living with schizophrenia generally show psychomotor poverty, incoordination and clumsiness, and have an impairment of motor skill learning, which have been suggested to be linked to a dysfunctional motor execution system. It is widely documented in psychological and neurocognitive studies that the systems that mediate action perception, simulation, imitation, planning and execution overlap and interact with each other. These studies have supported the view that when we observe others actions, observed action is automatically simulated and matched with internal motor representation. These externally triggered motor representations are then used to understand, rehearse, learn and reproduce the observed behavior. Therefore, for understanding, learning and acquiring new skills, the process of action perception is as important as that of motor execution. Recent studies have suggested that body-selective extrastriate body area (EBA) in the posterior temporal-occipital cortex is involved not only in static visual perception of body parts but also in the planning, imagination and execution of actions However, functional abnormality of the EBA in schizophrenia has yet to be investigated. Methods: Twelve schizophrenia patients (6 men and 6 women) and 12 age-sex-matched control participants participated in the study. Using functional magnetic resonance imaging (fMRI) with a task designed to activate the EBA by goal-directed actions, we aimed to elucidate functional abnormality of the EBA during observation of goal-directed actions in patients with schizophrenia. Results: Compared to controls, the patients with schizophrenia demonstrated significantly less activation in the EBA during observation of sports-related goal-directed actions. Furthermore, the EBA activation in patients was negatively correlated with the severity of negative and general psychopathology symptoms measured by the Positive and Negative Syndrome Scale. Conclusions: Dysfunction of the EBA might reflect a difficulty in representing dynamic aspects of human actions and might lead to impairments of simulation, learning and execution of actions in schizophrenia. Furthermore, these impairments might lead to impairments of understanding others actions, interpersonal communication, body awareness, and overall physical activity manifested as negative symptoms and general psychopathology symptoms. The results of this study seem to have some important clinical implications for the management of schizophrenia and merit further investigation of the role of sports participation/observation in the rehabilitation for schizophrenia and their effects on EBA function. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本統合失調症学会第3回大会 | |||||
発表年月日 | ||||||
日付 | 2008-03-15 | |||||
日付タイプ | Issued |