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CT-based dose-volume parameters of the rectum and late rectal complications in patients with cervical cancer treated with high-dose-rate intracavitary brachytherapy
https://repo.qst.go.jp/records/62536
https://repo.qst.go.jp/records/625367c43f167-2a1f-47f8-bb63-fcca1c4a86c9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-15 | |||||
| タイトル | ||||||
| タイトル | CT-based dose-volume parameters of the rectum and late rectal complications in patients with cervical cancer treated with high-dose-rate intracavitary brachytherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Shingo
× Kato, Shingo× Kiyohara, Hiroki× Tamaki, Tomoaki× Ohno, Tatsuya× Tsujii, Hirohiko× Nakano, Takashi× 加藤 眞吾× 清原 浩樹× 田巻 倫明× 大野 達也× 辻井 博彦× 中野 隆史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the efficacy of CT-based dose-volume parameters of the rectum as the predictive factors for late rectal complications (LRC) in patients with cervical cancer treated with radiotherapy alone. \nMethods and Materials: Eighty-four patients treated with radiotherapy alone between January 2000 and December 2004 were retrospectively analyzed. All patients received the combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). The median total dose of EBRT was 50 Gy, consisting of whole pelvic irradiation and central shielding pelvic irradiation. The median total dose to point A in HDR-ICBT was 24 Gy in 4 fractions. HDR-ICBT was prescribed using X-ray based two-dimensional dosimetry and planning. Patients underwent CT scans of the pelvis with the applicators in place to generate three-dimensional dose distributions. The external contours of the rectum were delineated on the CT images, and the minimum doses delivered to 0.1cc, 1cc, 2cc, and 5cc of the most irradiated rectal volumes were determined from the dose-volume histgrams. The ICRU rectal reference point dose was derived from the conventional method. The doses in EBRT and ICBT were transformed to the biologically equivalent doses in 2 Gy fractions (EQD2) using a/B ratio of 3 Gy, and the total rectal doses for dose-volume parameters (D0.1cc, D1cc, D2cc, D5cc, and DICRU) were calculated. The correlation between the dose-volume parameters and the actuarial rate of LRC was analyzed. Results: The median follow-up duration for all patients was 46 months (range, 12-79 months). Twenty patients developed LRC (Grade 1: 12, Grade 2: 8). The 5-year actuarial rate of LRC was 27.4%. There was a statistically significant difference in D0.1cc, D1cc, D2cc, and D5cc between patients with and without LRC (p<0.001), whereas the difference in DICRU was not statistically significant (p=0.07). The 5-year LRC rates in patients with D2cc of 0-40 Gy, 40-50 Gy, 50-60 Gy, 60-70 Gy, 70-80 Gy, and 80Gy < were 0%, 19.6%, 11.4%, 41.9%, 50%, and 62.5%, respectively. Patients with D2cc > 60 Gy showed significantly greater incidence of LRC (p<0.001). When patients were grouped with DICRU, there was no significant difference in 5-year LRC rates among them. Conclusion: The present study suggests that CT-based dose-volume parameters may be good predictors of LRC in radiotherapy for cervical cancer. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ABS/GEC-ESTRO 2008 World Congress of Bracheytherapy | |||||
| 発表年月日 | ||||||
| 日付 | 2008-05-06 | |||||
| 日付タイプ | Issued | |||||
