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アイテム
Carbon Ion Radiotherapy for Hepatocellular Carcinoma (HCC, Hepatoma)
https://repo.qst.go.jp/records/62496
https://repo.qst.go.jp/records/62496969d57e1-82e2-42f1-8b02-11325cef3dad
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-28 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Hepatocellular Carcinoma (HCC, Hepatoma) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Katou, Hirotoshi
× Katou, Hirotoshi× Yasuda, Shigeo× Yamada, Shigeru× Yanagi, Takeshi× Hara, Ryusuke× Imada, Hiroshi× Kamada, Tadashi× Mizoe, Junetsu× Tsujii, Hirohiko× 加藤 博敏× 安田 茂雄× 山田 滋× 柳 剛× 原 竜介× 今田 浩史× 鎌田 正× 溝江 純悦× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The objective of this paper is to present a summary explanation of the clinical study on carbon ion radiotherapy for hepatocellular carcinoma (HCC) which has been conducted since April 1995 to August 2005 at the Research Center for Charged Particle Therapy, National Institute of Radiation Sciences in Japan. A total of 193 patients with HCC were enrolled on the clinical trials with carbon ion beams. In the first and second phase I/II clinical trials, dose escalation experiments were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and the effectiveness in a short-course regime of 12, 8 and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed, where forty-seven patients were treated with low toxicity, high local control rate of 96% at 5 years. The last clinical study was conducted from April 2003 to August 2005 with an even more hypofractionated regime of 2 fractions/2 days, in which thirty-six patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. There were no therapy-related deaths and no severe adverse events throughout the trials. We can conclude that because of the low toxicity and high local control rate, carbon ion radiotherapy has a promising potential as a new, radical, and minimally invasive therapeutic option for HCC. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy | |||||
| 発表年月日 | ||||||
| 日付 | 2008-03-22 | |||||
| 日付タイプ | Issued | |||||
