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放射線応答に対するGJICの役割は繊維芽細胞と癌細胞で異なる
https://repo.qst.go.jp/records/62367
https://repo.qst.go.jp/records/62367ab4c4ecb-b78e-4504-bc8b-8bda67af5fe5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-17 | |||||
| タイトル | ||||||
| タイトル | 放射線応答に対するGJICの役割は繊維芽細胞と癌細胞で異なる | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
邵, 春林
× 邵, 春林× 古澤, 佳也× 松本, 孔貴× 陳, 紅紅× 古澤 佳也× 松本 孔貴 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gap junctional intercellular communication (GJIC) is an important function of metazoan cells and is believed to play a role of enhancing irradiation-induced bystander responses and have beneficial effects in anti-tumor therapy. This study found that, when primary fibroblast AG1522 cells on confluent were irradiated with a 100 keV/um carbon-ion beam, the cell responses of micronuclei (MN) formation and G1-phase arrest had a low dose sensitivity effect that was positively regulated by the GJIC. Meanwhile, when neoplastic human salivary gland (HSG) cells were irradiated under the condition of confluent but with poor internal GJIC, MN and G2-phase arrest were induced. Unexpectedly, when GJIC between HSG cells were enhanced by treating of cells with 8-Br-CAMP, these radiation-induced cellular damage was reduced so that cell surviving fraction was slightly enhanced, suggesting that increased GJIC protects HSG cells from lethal radiation damage. Further investigation demonstrated that ROS were involved in the GJIC-enhanced radiation effect on AG1522 cells and nitric oxide contributed to the GJIC-reduced radiation effect on HSG cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第50回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-11-17 | |||||
| 日付タイプ | Issued | |||||
