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Nitroxyl Radicals: Electrochemical Approach to Structure-Activity Relationships
https://repo.qst.go.jp/records/62360
https://repo.qst.go.jp/records/6236087135f54-2e4b-4fac-a098-76df029d2996
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-17 | |||||
| タイトル | ||||||
| タイトル | Nitroxyl Radicals: Electrochemical Approach to Structure-Activity Relationships | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Manda, Sushma
× Manda, Sushma× Nakanishi, Ikuo× Ohkubo, Kei× Yakumaru, Haruko× Matsumoto, Kenichiro× Ozawa, Toshihiko× Ikota, Nobuo× Fukuzumi, Shunichi× Anzai, Kazunori× Ｍａｎｄａ Ｓｕｓｈｍａ× 中西 郁夫× 薬丸 晴子× 松本 謙一郎× 小澤 俊彦× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cyclic nitroxyl radicals (NRs) are well known as a spin label, superoxide dismutase (SOD) mimic, and antioxidant. The redox property of NRs play lead role to control their reactivity. The redox electrochemistry, i.e., electrochemically forced removal or addition of an electron, is affected by the structure and stereochemistry of the compounds, solvents used for the electrochemical analysis, and also the various experimental parameter settings. So it is quite important to find out the structure-activity relationships of structurally different NRs by keeping constant all other parameters affecting reactivity of NRs. This allows the selection of most suitable NRs among the present NRs and also allows finding out the way for structural modification of NRs towards the better reactivity. In this study, one-electron redox potentials of five nitroxyl radicals with different substituents at the beta-position were measured in two different solvents, methanol and aqueous phosphate buffer (0.1 M, pH 7.4), by cyclic voltammetry and second-harmonic alternating current voltammetry. Evaluations of obtained data revealed the direct correlation between one-electron redox potentials and electronegativities of the beta-substituent on the ring. beta-Substituent with electron-donating effect caused negative shift in the one-electron redox potentials of the NRs and beta-substituents with electron-withdrawing effect behaved reversely. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第22回日本酸化ストレス学会関東支部会 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-12-14 | |||||
| 日付タイプ | Issued | |||||
