WEKO3
アイテム
アスベスト発がんにおけるフェリチンH鎖の役割
https://repo.qst.go.jp/records/62258
https://repo.qst.go.jp/records/622580c9b2055-a564-49a7-8d45-4bd08a8c3367
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-15 | |||||
| タイトル | ||||||
| タイトル | アスベスト発がんにおけるフェリチンH鎖の役割 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 純崇
× 長谷川, 純崇× Ｕ, Ｗｉｎｎ Ａｕｎｇ× 古川, 高子× 佐賀, 恒夫× 長谷川 純崇× Ｕ Ｗｉｎｎ Ａｕｎｇ× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to asbestos is a known etiological factor in malignant mesothelioma (MM). However, in vitro cell culture studies have provided paradoxical evidence that asbestos exposure to mesothelial cells causes cytotoxicity or apoptosis rather than malignant transformation. Here we demonstrate that ferritin heavy chain (FHC), a core subunit of iron-binding protein ferritin, works as an anti-apoptotic protein against toxic asbestos and oxidative stress in human mesothelial cells and MM cells. We found that FHC was induced in asbestos-exposed MeT-5A human mesothelial cells. The mesothelial cell line stably expressing FHC generated less amount of hydrogen peroxide (H2O2), one of the main ROS, after asbestos exposure and was more resistant to apoptosis induced by H2O2 compared with the cells transfected with the empty vector. We also found that NCI-H2052, a human MM cell line, had a higher expression of endogenous FHC than MeT-5A and showed apoptosis resistant phenotype. Suppression of the over-expressed FHC by using FHC siRNA rendered the MM cells sensitive to apoptosis. Our findings highlight the potential role of FHC in the pathogenesis of asbestos-induced mesothelioma. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第66回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-10-05 | |||||
| 日付タイプ | Issued | |||||
