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Brain Tissue Oxygen Consumption and Supply Induced by Neural Activation: Determined under Suppressed Hemodynamic Response Conditions in the Anesthetized Rat Cerebral Cortex
https://repo.qst.go.jp/records/62199
https://repo.qst.go.jp/records/6219979349731-3ca4-438a-bf3f-22a210b82b7d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-09-06 | |||||
| タイトル | ||||||
| タイトル | Brain Tissue Oxygen Consumption and Supply Induced by Neural Activation: Determined under Suppressed Hemodynamic Response Conditions in the Anesthetized Rat Cerebral Cortex | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Masamoto, Kazuto
× Masamoto, Kazuto× Vazquez, Alberto× Wang, Ping× Kim, Seong-Gi× 正本 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The changes in cerebral metabolic rate of oxygen (CMRO2) and supply induced by neural activity were determined based on measurements of tissue partial pressure of oxygen (Po2) under suppressed hemodynamic response conditions. Sodium-nitroprusside (sNP) was used to suppress evoked cerebral blood flow (CBF), while the evoked neural activity remained intact. Under control conditions (before sNP injection), the evoked CBF and Po2 showed ~50% and ~20% increases, respectively. With the sNP injection, the evoked CBF was suppressed (< ~6% at peak) whereas the Po2 monotonically decreased (~ -10%). These results indicated that the Po2 reduction without CBF response is directly related to the CMRo2 changes. A model of oxygen exchange from blood to tissue was used to calculate the absolute value of the resting and activated CMRo2 levels; 6.8  2.2 and 7.4  2.2 ml O2/100 g/min, respectively. The CMRO2 changes were linearly related with the sum of evoked field potentials (0.012 ml O2/ 100 g/ min/ mV), indicating a reliable index of evoked neural activity. The comparison of Po2 changes with and without CBF response revealed that the about 2.5 times supply of oxygen with respect to the increased demand is produced by the CBF response. The model also predicted that this oversupply results from the significant rise in the arteriolar end oxygenation level (82% to 90% SO2) in addition to the increase in CBF. The caution should be excised in the calculation of tissue CMRo2 changes based on a measurement of blood oxygenation levels. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ISOTT 2007 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-08-30 | |||||
| 日付タイプ | Issued | |||||
