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Multiple genetic variants associated with risk of adverse skin reactions following radiotherapy in breast cancer patients.
https://repo.qst.go.jp/records/62149
https://repo.qst.go.jp/records/621491f1479ae-ff15-4f7b-8e41-9b0297ca05a4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-17 | |||||
| タイトル | ||||||
| タイトル | Multiple genetic variants associated with risk of adverse skin reactions following radiotherapy in breast cancer patients. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imai, Takashi
× Imai, Takashi× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiotherapy for breast cancer patients occasionally induces adverse effects. The adverse reactions to radiotherapy are caused by multiple factors, including individual genetic differences. The heterogeneity in normal tissue reactions may result from the combined effect of several different genetic alterations. Single nucleotide polymorphisms (SNPs) and derived haplotypes within multiple genes may be used to detect the genetic alterations related to the heterogeneity in normal tissue reactions. In our previous study, a multi-institutional study of nongenetic risk factors, such as operative procedure, magnitude of photon energy, and the use of multi-leaf collimeters, for adverse skin reaction (ASR) to radiotherapy among breast cancer patients were tested, and in the current study, only patients who were eligible for genetic analysis were enrolled. DNA samples were collected from 399 breast cancer patients. Using the NCI-CTC scoring system, the patients were grouped according to ASR within 3 months of starting radiotherapy (grade ≤ 1, n = 290 and ≥ 2, n = 109). The candidate genes for genotyping were selected by our gene expression analysis of mouse strains with different radiosensitivity, expression analysis of human cell lines with varied radiosensitivity, and bibliographic search. In total, 486 SNP sites on 99 genes which were polymorphic (allele frequency >5%) were analyzed. Variations in the candidate genes were considered as haplotypes because the statistical power of association tests using phased data is likely to increase and because analysis of haplotype frequencies enables the detection of predisposing haplotypes, even without typing the true functional SNP. Linkage disequilibrium maps were constructed and haplo-tag SNPs were selected for each locus. Global haplotype analysis using the Haplo.stats program indicated that estimated haplotypes in 6 loci, PTTG1, MAD2L, REV3, LIG3, RAD9A and CD44, were associated with ASR risk. In conclusion, Individual radiosensitivity may be partly determined by combinations of these haplotypes in multiple loci. This would provide an understanding of the mechanisms underlying the genetic variation in radiation sensitivity or resistance among the population, and would show the possibility of prediction of the risk of ASR prior to radiation therapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
