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Combined genotoxicity of low-dose-rate radiation and tobacco-specific nitrosamine NNK
https://repo.qst.go.jp/records/62125
https://repo.qst.go.jp/records/62125b4208eed-708e-41b0-9b6a-5046eee328ef
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-19 | |||||
| タイトル | ||||||
| タイトル | Combined genotoxicity of low-dose-rate radiation and tobacco-specific nitrosamine NNK | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nohmi, Takehiko
× Nohmi, Takehiko× Ikeda, Megumi× Masumura, Kenichi× Sakamoto, Yasuteru× Bing, Wang× Nenoi, Mitsuru× Hayata, Isamu× et.al× 能美 健彦× 池田 恵× 増村 健一× 坂元 康晃× 王 冰× 根井 充× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Health effects of low-dose-rate or low-dose radiation should be evaluated in combination with chemicals as humans are exposed to a variety of chemicals. Here, we report combined genotoxic effects of low-dose-rate radiation and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the most carcinogenic tobacco-specific nitrosamine, in the lung of gpt delta transgenic mice. In this mouse model, base substitutions and deletions can be separately analyzed at the molecular level. Female gpt delta transgenic mice were either treated with gamma-irradiation alone at a dose rate of 0.5, 1.0 or 1.5 mGy/h for 22 h/day for 31 days or combined with NNK treatments at a dose of 2 mg/mouse/day, i.p. for four consecutive days in the middle course of irradiation. The NNK treatments enhanced the frequency of base substitutions significantly, but no obvious combined effects of irradiation were observed. In contrast, the NNK treatments appeared to suppress radiation-induced large deletions. The frequency of large deletions more than 1 kb in size increased in a dose-dependent manner of gamma irradiation. When NNK treatments were combined, the dose-response curve became bell-shaped where the frequency at the highest radiation dose decreased substantially. Possible mechanisms underlying the combined genotoxicity of radiation and NNK are discussed, and the importance of evaluation of combined genotoxicity of more than one agent is emphasized. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 20th CODATA International Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2006-10-25 | |||||
| 日付タイプ | Issued | |||||
