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Carbon ion radiotherapy in hypofraction regimen for stage I non-small cell lung cancer
https://repo.qst.go.jp/records/61978
https://repo.qst.go.jp/records/619782cbea851-2dc1-466b-aeeb-4886130fd519
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-01-12 | |||||
| タイトル | ||||||
| タイトル | Carbon ion radiotherapy in hypofraction regimen for stage I non-small cell lung cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Miyamoto, Tadaaki
× Miyamoto, Tadaaki× 宮本 忠昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background. Carbon ion radiotherapy is a promising modality because of its excellent dose localization and high biological effects on a tumor. In the present study, fixing the total dose was fixed at 72 GyE in 9 fractions over 3 weeks, and at 52.8 GyE for stage 1A and at 60 GyE for stage 1B over one week, Using these fractionation schedules, we conducted a phase 2 clinical trial for stage NSCLC from 1999 to 2003 determine the local control and the survival rates. Methods. One hundred twenty nine patients with 133 primary lesions were treated. The average age of the patients was 74.5 years. The patient population consisted of, 92 males and 37 females. The T1 and T2 numbers were 72 and 59, respectively. The average tumor size (diameter) was 31.5mm. By type, the tumors broke down into 85 adenocarcinomas, 43 squamous cell carcinomas, two large cell carcinomas and one adenosquamous cell carcinopma. A primary tumor was treated with carbon beam alone using the fixed total dose of 72 GyE in 9 fractions over 3 weeks, and 52.8 GyE for stage 1A and 60 GyE for stage 1B over one week. Most of targets were irradiated from obliquely from four directions. A respiratory-gated irradiation system was used for irradiation in each case. Local control and survival were determined by using the Kaplan-Meyer method and the data were statistically processed by using the long-rank test. Results. The local control rate for all patients was 95.2%. There was no statistical difference in the local control rate between T1 and T2 (p=0.063), and between the squamous and non-squamous type (p=0.208). The patients five-year cause-specific survival rate of them was 79.1% (IA: 90.3, IB: 63.2), and overall survival was 57.3% (IA: 63.1, IB: 50). No toxic reactions were observed in the skin and no adverse effects worse than grade 3 were detected. Conclusions. Carbon beam radiotherapy, a new therapy modality with superior benefits in terms of QOL and ADL, has been proven to be a valid alternative to surgery for stage I and to offer particular benefits especially for elderly and inoperable patients. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 11th Ｗｏｒｌｄ Ｃｏｎｇｒｅｓｓ ｏｎ Advances in Oncology and 9th International Symposium on Molecular Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2006-10-14 | |||||
| 日付タイプ | Issued | |||||
