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Carbon Ion Radiotherapy for Locally advanced Adenocarcinoma of the Uterine Cervix.
https://repo.qst.go.jp/records/61941
https://repo.qst.go.jp/records/61941e689bb55-ce14-400f-9880-73b319eed210
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-12-05 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Locally advanced Adenocarcinoma of the Uterine Cervix. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Shingo
× Kato, Shingo× Ohno, Tatsuya× Tsujii, Hirohiko× Suzuki, Michiya× 加藤 眞吾× 大野 達也× 辻井 博彦× 鈴木 通也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Purpose: To evaluate the toxicity and efficacy of carbon ion radiotherapy (CIRT) for locally advanced cervical adenocarcinoma by a phase I/II dose-escalation study. Methods and Materials: Between April 1998 and March 2006, 32 patients with cervical adenocarcinoma were treated with CIRT. Histologically, 24 patients had adenocarcinomas and 8 had adenosquamous carcinomas. Seven patients had stage IIB, 23 had stage IIIB, and 2 had stage IVA disease. The median tumor size was 6.5 cm. The treatment consisted of whole pelvic irradiation and local boost. The clinical target volume (CTV) of whole pelvic irradiation included the cervical tumor, uterus, parametrium, at least the upper half of the vagina, and pelvic lymph nodes. The dose of the whole pelvic irradiation was fixed at 36.0 gray equivalent (GyE) in 12 fractions. In local boost irradiation, the CTV was shrunk to the cervical tumor and surrounding tissues, and an additional dose of 26.4-35.2 GyE/8 fractions was delivered (total dose: 62.4-71.2 GyE). The dose to the GI tracts was limited to less than 60 GyE. The median follow-up duration for all patients was 21.5 months (range, 6-81 months). Results: No patient developed severe acute toxicity. No patient developed major late complications except for one patient with a rectovaginal fistula. Local control was obtained in 4 of the 7 patients receiving a total of 62.4-64.8 GyE, in 7 of the 9 patients receiving 68.0 GyE, and in 11 of the 13 patients receiving 71.2GyE. The 3-year overall survival rates for all patients and the 25 patients with stage IIIB or IVA disease were 66% and 60%, respectively. Conclusions: Although the number of patients was small, the results have suggested that CIRT provided favorable local tumor control and overall survival with acceptable rates of late complications in the treatment of locally advanced cervical adenocarcinoma. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | NIRS-CNAO Joint Symposium on Carbon Ion Radiotherapy | |||||
| 発表年月日 | ||||||
| 日付 | 2006-11-28 | |||||
| 日付タイプ | Issued | |||||
