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Dose-rate Effect of High-LET Ion Beams on Human Tumor Cells
https://repo.qst.go.jp/records/61719
https://repo.qst.go.jp/records/6171910a3eb33-e6e3-44ee-b13f-560d1c9797f1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-08-10 | |||||
| タイトル | ||||||
| タイトル | Dose-rate Effect of High-LET Ion Beams on Human Tumor Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furusawa, Yoshiya
× Furusawa, Yoshiya× Matsumoto, Yoshitaka× Hirayama, Ryoichi× Satou, Shinji× Satou, Yukio× Kanazawa, Mitsutaka× Tomitani, Takehiro× Ando, Koichi× 古澤 佳也× 松本 孔貴× 平山 亮一× 佐藤 眞二× 佐藤 幸夫× 金澤 光隆× 富谷 武浩× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is known that radiobiological effectiveness decrease with decrease of the dose-rate for gamma-rays or neutrons. Radiosensitivity as cell survival changes with the dose-rate between 0.2 Gy/hr and 60 Gy/hr (HP Leenhouts et al, J. Radiol. Prot. 10; 95-102, 1990) in mouse CHO cells. There are little reports concerning the dose-arte effects by exposure of ion-beams. Astronauts may receive very low-dose-rate ion-beam radiations. RBE is an important factor to estimate the risk of biological effects by ion-beams, however the RBE is usually estimated from the data at high-dose-rate. Thus, we studied the dose-rate effect on radiosensitivity for heavy ion-beams on cell survival. A human salivary grand tumor cells (HSG) cultured in Eagle's MEM medium in 5% CO2 conteining air at 37 Co was used. A 290 MeV/u carbon-ion beams having 70keV/um of the LET were used at HIMAC facility in the National Institute of Radiological Sciences, Chiba, Japan. Exponentially growing cells cultured in flasks (NUNC 170920) were irradiated with different doses up to about 4.5 Gy that corresponds the cell survival reduce to be less than 1 %, with different dose-rate between 0.5 and 600 Gy/hr. Irradiated cells were sub-cultured just after the exposure, incubated for 13 days, and then colonies consists more than 50 cells were counted as survived cells. The data were plotted on a usual semi logarithmic chart, and compare the survival curves with different dose-rate. All the data from different lower dose-rate exposure plotted on a curve produced by high-dose-rate (10 Gy/min) experiments. It is also found that there are no significant changes in survival parameters by the dose-rate. The survival curve parameters, such as alpha, beta, and D0 were 0.86 Gy-1, 0.10 Gy-2, and 0.78 Gy at 10 Gy/min experiments, and the values varied among 0.69-1.11 Gy-1, 0.05-0.15 Gy-2, and 0.74-0.83 Gy, respectively. In conclusion, the dose-rate effect on cell survival could not observe in the dose-rates tested (611-0.49 Gy/hr) on the cells used (HSG). Alternation of the dose-rate may not affect at the estimation of RBE. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 36th COSPAR Scientific Assembly | |||||
| 発表年月日 | ||||||
| 日付 | 2006-07-23 | |||||
| 日付タイプ | Issued | |||||
