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Evaluation of Reference Tissue Models for the Quantitative Analysis of [11C]PE2I Binding in Human Brain
https://repo.qst.go.jp/records/61675
https://repo.qst.go.jp/records/6167527e3f16e-b971-44a9-86e0-8a3d6d3e1aa7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-13 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Reference Tissue Models for the Quantitative Analysis of [11C]PE2I Binding in Human Brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Seki, Chie
× Seki, Chie× Ito, Hiroshi× Ichimiya, Tetsuya× Arakawa, Ryosuke× Ikoma, Youko× Maeda, Jun× et.al× 関 千江× 伊藤 浩× 一宮 哲哉× 荒川 亮介× 生駒 洋子× 前田 純 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Dopamine transporter (DAT) plays an important role in presynaptic dopaminergic functions. [11C]PE2I is a highly selective PET ligand for neuronal DAT, and excellent in vivo PET imaging was reported in monkey and human brain [1]. The aim of this study was to find suitable reference tissue model (RTM) for describing tracer kinetics. We analyzed the [11C]PE2I kinetics with metabolite-corrected arterial input function, then we attempted to estimate distribution volume ratio (DVR) with RTMs using cerebellum (CB) as the reference region. The results were compared and assessed the applicability of RTMs with the assistance of a simulation study. Methods: Dynamic PET scans were performed in 6 young healthy male volunteers after intravenous bolus [11C]PE2I (197-230Mq, 644-1104 GBq/micromole) injections. The metabolite-corrected arterial plasma input functions were obtained. Regions of interest (ROIs) were determined to obtain regional time activity curves (TACs). The TACs were analyzed with the kinetic and graphical approach [2] to obtain regional distribution volume (Vd) using the plasma input function. Then a regional Vd was divided by Vd of CB to determine DVR. The TACs were analyzed with original multilinear reference tissue model (MRTMo) [3] and simplified reference tissue model (SRTM) [4]. A simulation study was also performed to assess the applicability of RTMs. Results: The highest [11C]PE2I accumulation was observed in the striatum, followed by midbrain and thalamus. DVRs in midbrain and thalamus determined by graphical approach were 1.53+/-.25 and 1.25+/-.13 respectively. The 3-compartment model was better than 2-compartment model to describe the [11C]PE2I kinetics in CB. The simulation revealed that RTMs caused an underestimation of DVR in the striatum when tracer kinetics in a reference tissue was described by 3-compartment model. DVR values determined by the MRTMo were in good agreement with those by the graphical approach in extrastraital regions (r=0.97). Conclusion: MRTMo is a suitable RTM for the quantification of [11C]PE2I binding in extrastraital regions, in which the DVR levels are considerably low. Since extrastiatal DAT has become of interest in brain function [5], this noninvasive quantitative analysis will be useful in clinical investigations. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Sixth International Symposium on Neuroreceptor Mapping | |||||
| 発表年月日 | ||||||
| 日付 | 2006-07-08 | |||||
| 日付タイプ | Issued | |||||
