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Combined effects of ionizing radiation and N-ethyl-N-nitrosourea in murine T-cell lymphomagenesis
https://repo.qst.go.jp/records/61554
https://repo.qst.go.jp/records/61554e6cbe36e-5889-4938-80db-dadfdc34a8f3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-03 | |||||
| タイトル | ||||||
| タイトル | Combined effects of ionizing radiation and N-ethyl-N-nitrosourea in murine T-cell lymphomagenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Amasaki, Yoshiko× Yamauchi, Kazumi× Nishimura, Mayumi× Imaoka, Tatsuhiko× Shimada, Yoshiya× 柿沼 志津子× 甘崎 佳子× 山内 一己× 西村 まゆみ× 今岡 達彦× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We are living in the environment with numerous natural and man-made radiation and chemicals. Cancer development in human is considered as a result of interaction with these factors. But, the quantitative assessment and mechanistic understanding of combined effects of radiation and chemical carcinogens are still insufficient. The aim of this study is to elucidate the mode and mechanism of the combined effect of X-rays with N-ethyl-N-nitrosourea (ENU) on mouse T-cell leukemogenesis, especially at low or threshold dose range. We previously showed that the dose-response curve for X-ray- or ENU-induced thymic lymphoma (TL) had threshold dose. X-ray-induced TL was characteristic for frequent inactivation of Ikaros caused by transcriptional silencing, unusual splicing, point mutation and small insertion, most of which were associated with loss of heterozygosity (LOH). In contrast, ENU-induced tumors had point mutations of Ikaros without LOH. In combination, X-irradiation followed by ENU exposure resulted in the synergistic effect at high dose, while the effect was antagonistic at low or threshold dose. When the order of exposure was reversed, i.e., ENU followed by X-rays, the mode of combined exposure was additive at any doses. Molecular analysis demonstrated that Ikaros mutation in TL after X-irradiation followed by ENU at high doses was predominantly point mutation without LOH (ENU-type). But, after reverse treatment, mutation spectrum of Ikaros was similar to that observed in TL after X-ray exposure alone. It is concluded that the mode of combined effect is dependent upon the treatment order and the dose of carcinogens. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 6th Japan-France Workshop | |||||
| 発表年月日 | ||||||
| 日付 | 2006-06-23 | |||||
| 日付タイプ | Issued | |||||
