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Intratumoral Distribution of Cu-ATSM and FDG: Immunohistochemical characterization of the region with high Cu-ATSM or FDG accumulation
https://repo.qst.go.jp/records/61521
https://repo.qst.go.jp/records/6152194bf2be7-37b1-47fc-9381-c0bdc9bf9c09
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-26 | |||||
| タイトル | ||||||
| タイトル | Intratumoral Distribution of Cu-ATSM and FDG: Immunohistochemical characterization of the region with high Cu-ATSM or FDG accumulation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furukawa, Takako
× Furukawa, Takako× Saga, Tsuneo× Fujibayashi, Yasuhisa× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Intratumoral distribution of [Cu-64]Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) and fluorine-18 2-fluoro-2-deoxyglucose (18FDG) in mice bearing tumors of four different origins, LLC1(Lewis lung carcinoma), Meth-A (sarcoma), B16(melanoma) and colon26(adenocarcinoma), were compared to the immunohistochemical staining for proliferating cells (Ki67), blood vessels (CD34 or von Willebrand Factor(vWF)) and apoptotic cells (terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) method). With all the cell lines, 64Cu-ATSM and 18FDG were distributed to different regions of the tumor mass. The immunohistochemical study demonstrated that the high 64Cu-ASTM uptake regions were hypovascular and consisted of tumor cells arrested in cell cycle, while the high 18FGD uptake regions were hypervascular and consisted of proliferating cells. Through our study, it was revealed that one tumor mass contains two regions of different characteristics, which can be distinguished by 64Cu-ATSM and 18FDG. Since hypoxia and cell cycle arrest are critical factors to reduce the sensitivity of tumor to radiation and conventional chemotherapy, regions with such characteristics in tumor should be treated intensively as one of the primary targets. 64Cu-ATSM which can delineate hypoxic and cell cycle arrested regions in tumors can provide valuable information for cancer treatment as well as the possibility to treat such regions directly as an internal radiotherapy reagent. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第６回放射線生物学および画像医学に関する日仏ワークショップ | |||||
| 発表年月日 | ||||||
| 日付 | 2006-06-23 | |||||
| 日付タイプ | Issued | |||||
