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Ratio of Dicentrics vs Translocations Induced by Radiation
https://repo.qst.go.jp/records/61510
https://repo.qst.go.jp/records/61510395ac5cb-9e01-48af-bbc6-d147eaa5690e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-23 | |||||
| タイトル | ||||||
| タイトル | Ratio of Dicentrics vs Translocations Induced by Radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Wei
× Zhang, Wei× Hayata, Isamu× 張 偉× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Theoretically translocations and dicentrics should be induced by radiation at an equal rate. However, most papers have reported that translocations are observed slightly more often than dicentrics after exposure to radiation. In order to learn the reason why translocations are induced more than dicentrics, induction rates of the dicentrics and translocations involving chromosomes 2 and 4 in peripheral lymphocytes irradiated with X-rays at a dose of 3Gy were examined using a conventional Giemsa staining method and a chromosome painting method. A total of 228 reciprocal exchanges detected in 982 metaphases were classified into three groups according to the break points of the original chromosomes. The incidents of both acentric fragments being larger than half of the original chromosome (combination 1) was only seven (3%), and did not contribute significantly to induction rates. When the broken acentric fragments of two affected chromosomes were smaller than half of the original chromosomes (combination 2), which was found in 175 (77%) of the rearrangements, the induction rates of dicentrics and translocations were about the same (86:89). But if the sizes of the broken segments were unequal in both chromosomes (combination 3: one with a larger acentric part and the other with a smaller acentric part), the yield of dicentrics was significantly lower than that of translocations (16:30). It was found that preferential reduction of dicentrics in reciprocal exchanges originated from the heteromorphic size of broken chromosomes in the last combination. The mechanism of this preferential reduction is unknown. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第48回大会第1回アジア放射線研究会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2005-11-17 | |||||
| 日付タイプ | Issued | |||||
