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Experimental Study on radiation-Induced Adaptive Response in Fetal Mice
https://repo.qst.go.jp/records/61508
https://repo.qst.go.jp/records/615089b167c96-4d1a-4419-b458-63dc0403b9fb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-22 | |||||
| タイトル | ||||||
| タイトル | Experimental Study on radiation-Induced Adaptive Response in Fetal Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× 王 冰 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced adaptive response is a complicated phenomenon in radiobiology. Its study provides an important scientific basis for radiation risk estimates. As with previous research on cultured cells and in adult animals, an adaptive response in fetal mice could be induced only when application of irradiation and animal factors met a set of strict conditions. As the characterization of essential conditions offers significant insight into the novel biological defense mechanisms involved in radiation protection, a series of experimental trails on those conditions was performed. The findings were that there was a specific interval (one day) between the priming dose and the challenging dose, reduced digital defects were correlated to the suppression of apoptosis, there was one efficient priming dose for ICR mice (0.3Gy) and two for C57BL/6J mice (0.05 and 0.3Gy), both Trp53 alleles were essential, and there were two differential dose-rate ranges (0.18-0.98Gy/min, 3.5-4.6Gy/min) efficient for the same priming dose in ICR mice. These findings suggest the existence of multiple pathway of signal transduction activated by the priming irradiation, and multiple cell population with various susceptibilities to radiation may be involved. The decrease irradiation-induced apoptosis implies the involvement of an anti-apoptotic pathway, and thus further study on apoptosis-related genes is probably warranted. These findings imply that there is no consistent pattern for successful induction in regard to the complex interplay between the inducting system and biological subjects. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第48回大会及び第1回アジア放射線研究会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2005-11-17 | |||||
| 日付タイプ | Issued | |||||
