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First human brain images of the jPET-D4: a novel 4-layer depth-of-interaction PET scanner
https://repo.qst.go.jp/records/61452
https://repo.qst.go.jp/records/614528b94681e-1e3a-4c0f-97cf-098c7093a884
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | First human brain images of the jPET-D4: a novel 4-layer depth-of-interaction PET scanner | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamaya, Taiga
× Yamaya, Taiga× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Improvement of scanner sensitivity is an important issue for PET. Better scanner sensitivity enables not only quantitative imaging but also shorter scan time, reduced radiation dose and shorter time-frame intervals. The jPET-D4 is a high-performance brain PET scanner which achieves not only high spatial resolution but also high scanner sensitivity by measuring 4-layer depth-of-interaction (DOI) information. At this stage, we have developed a full-ring prototype scanner and 3D image reconstruction software. In this work, we present the first human brain images obtained with the jPET-D4 prototype. \nMethods: The scanner has 5 rings of 24 detector blocks each, and the detector block consists of 1,024 GSO crystals (2.9 mm x 2.9 mm x 7.5 mm) with two different amounts of cerium dopant, which are arranged in 4 layers of 16 x 16 arrays. This scanner is dedicated to brain scans, and the detector rings have a diameter of 390 mm. The basic idea for DOI discrimination is the coded reflector insertion that controls the distribution of scintillation light so that each position can be identified by the Anger type calculation. Four-layer DOI positions are identified based on this idea after upper and lower two DOI positions are separated by the pulse shape discrimination. In order to reduce computational cost while retaining the advantage of DOI information in iterative image reconstruction, we used (a) the DOI compression (DOIC) method which reduces data dimensions with suppressing resolution loss, and (b) the approximated system model which enables fast system matrix calculation while preserving image quality. In addition to the on-the-fly system matrix calculation, (c) a pre-computed system matrix scheme was newly proposed to speed up 3D image reconstruction. At this development stage, histogram-based 3D OSEM was implemented. After evaluating basic imaging performance though phantom experiments, a normal volunteer was scanned (100 min past 104MBq FDG injection, duration 66 min) and the first human brain images were obtained. \nResults: The phantom studies show that almost uniform spatial resolution of 2-3 mm is obtained over the field-of-view by using the 4-layer DOI information. The human brain images show the excellent imaging performance of the jPET-D4: clear demarcations of thin gray matter from underlying white matter as well as fine visualization of the deep structures such as caudate nucleus, putamen and thalamus. \nConclusions: The first human brain images show the excellent imaging performance of the jPET-D4. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 53rd Annual Meeting of the Society of Nuclear Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2006-06-07 | |||||
| 日付タイプ | Issued | |||||
