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Carbon Ion Radiotherapy for Hepatocellular Carcinoma: Phase I/II and Phase II Clinical Trials
https://repo.qst.go.jp/records/61073
https://repo.qst.go.jp/records/6107362b27c0d-6508-43c9-bd3e-b8d52cf8149f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-09-09 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Hepatocellular Carcinoma: Phase I/II and Phase II Clinical Trials | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Katou, Hirotoshi
× Katou, Hirotoshi× Yamada, Shigeru× Yasuda, Shigeo× Maeda, Yukiteru× Kamada, Tadashi× Mizoe, Junetsu× Ootou, Masao× Tsujii, Hirohiko× 加藤 博敏× 山田 滋× 安田 茂雄× 前田 幸輝× 鎌田 正× 溝江 純悦× 大藤 正雄× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the safety and efficacy of carbon ion radiotherapy (CIRT) for hepatocellular carcinoma (HCC) Patients and Methods: Eligibility criteria for this study were as follows: biopsy-proven HCC; recurrent or residual tumor after other ineffective treatments or no indication for any other treatment; no tumor thrombosis of the portal main branch; no other viable lesion outside the planning target volume; no prior radiotherapy for target tumors; hepatic disorder of Child-Pugh grade A or B; Karnofsky performance status of 60-100; no other active cancer; and digestive tract not in contact with clinical target volume. CIRT was administered in 15 fractions for 5 weeks for 24 patients, 12 fractions for 3 weeks for 34 patients, 8 fractions for 2 weeks for 24 patients, 4 fractions for 1 week for 75 patients, or 2 fractions for 2 days for 32 patients within Phase I/II or Phase II clinical trials. Total dose ranged from 49.5 cobalt gray equivalent (GyE) in 15 fractions to 38.8 GyE in 2 fractions. Results: Between April 1995 and February 2005, 189 patients were totally enrolled. The subjects of this report were 181 patients with follow-up period of over 6 months, 13 of whom were twice treated with CIRT in this study. Therefore, the number of subjects for local control and survival analysis was 181 and 168, respectively. The survival period was calculated from the day of commencement of the first CIRT. The median age at therapy was 68 years (range, 37-84 years). All the patients had chronic liver diseases of Child-Pugh grade A in 145, B in 33, and inevaluable in 3. Ninety-six patients (53%) had intrahepatic recurrent lesions. The median tumor size was 4.0 cm in diameter (range, 1.2-12.0 cm). During a median follow-up of 58 months (range, 8-118 months), no hepatic failure resulting from the therapy and no treatment-related death occurred. Incidence of grade 3 early hepatic toxicity according to NCI-CTC was 13%, 1%, 2%, 8%, and 0% in the serum-GPT, ALB, T.BIL, prothrombin activity (PT%) and ALP, essential valuables concerning hepatic function, respectively. No grade 4 toxicity occurred with exception of 1 patient in T.BIL. No other grade 3 or worse adverse effect occurred. In 92% and 81% of the evaluable patients, the Child-Pugh score did not increase by more than 1 point in the early and late phase, respectively. Local control rate was 94%, 88%, and 88% at 1, 3, and 5 years, respectively. Overall survival rate was 93%, 54%, and 29% at 1, 3, and 5 years, respectively. The rate in the 27 patients initially treated with CIRT of 52.8GyE/4-fraction in the phase II study was 96% and 71% at 1 and 3 years, respectively, that was comparable with that in the hepatic resection in Japan. Conclusion: Carbon ion radiotherapy for hepatocellular carcinoma, especially short-course carbon ion radiotherapy of 52.8GyE/4-fraction, seems to be safe and effective, and to have a promising potential as a new, radical, and minimally invasive therapeutic option for Hepatocellular Carcinoma. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第42回 Particle Therapy Co-operative Group Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2005-06-10 | |||||
| 日付タイプ | Issued | |||||
