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アイテム
Effects of Low Dose Particle Radiation to Mouse Neonatal Neurons in Culture
https://repo.qst.go.jp/records/60493
https://repo.qst.go.jp/records/60493d1198b64-94e4-46f8-a896-5981e6ddb590
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-07-29 | |||||
| タイトル | ||||||
| タイトル | Effects of Low Dose Particle Radiation to Mouse Neonatal Neurons in Culture | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nojima, Kumie
× Nojima, Kumie× E., Vazquez Marcelo× Okayasu, Ryuichi× 野島 久美恵× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate effects of low dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0.05Gy up to 2.0Gy. The subsequent biological effectswere evaluated by an induction of apoptosis and neuron survival focusing on the dependencies of the animal strains, SCID, B6, B6C3F1, C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to particle radiation as evaluated by 10% apoptotic criterion. The LET dependency was compared with using SCID and B6 cells exposing to different ions (H, C, Ne, Si, Ar, and Fe). Although no detectable LET dependency was observed in the high LET (55 -200 keV/mm) and low dose (<0.5 Gy) regions. The survivability profiles of the neurons were different in the mouse strains and ions. In this repot, a result of memory andlearning function to adult mice after whole-body and brain local irradiation at carbon ion and iron ion. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 35th COSPAR Scientific Assembly 2004 | |||||
| 発表年月日 | ||||||
| 日付 | 2004-07-25 | |||||
| 日付タイプ | Issued | |||||
