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Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice.
https://repo.qst.go.jp/records/60273
https://repo.qst.go.jp/records/60273fdb3ea6e-363c-4014-a7c5-9aa1cc34ec9a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-02-16 | |||||
| タイトル | ||||||
| タイトル | Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Noda, Syuuhei× Oota, Toshie× Iwata, Masaru× Gotou, Miyako× Tanaka, Hiroko× Harada, Yoshinobu× Imai, Takashi× 岩川 眞由美× 野田 秀平× 太田 敏江× 岩田 賢× 中渡 美也子× 田中 裕子× 原田 良信× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim Radiotherapy for the treatment of cancer is limited by the tolerance of normal tissues within the treatment area. In this study, late phase of erythema, as a sequential endpoint of radiation effects on ski, and leg contracture as an endpoint for slowly responses of normal tissues was investigated among three strains of mice. We also examined the expression profiles of several genes to gain insights into inter-strain differences in radiosensitivity. \nMethods Mice of the inbred strains A/J, C57BL/6J, and C3H/HeMs, were irradiated using gamma rays at graded doses ranging from 10 to 60 Gy. The late skin reaction was scored for 300 days. Leg contracture assay was performed by measurement of extensibility of the hind legs of each mouse. Gene expression in the skin irradiated was quantified by quantitative RT-PCR assay. \nResults The three different strains showed various degrees of susceptibility to irradiation. Large inter-strain differences were also detected in the lengths of contracture. The expression of Alad, Cap1, Il18 and Rad51ap1 increased in A/J, and C3H/HeMs, and that of Mmp12 increased 12 hours after irradiation in A/J mice. The expression of Ang and that of Rad51ap1 increased 72 and 1 hours after irradiation in C3H/HeMs mice respectively. \nConclusions The continuum model of tissue injury supports the investigation of mechanism of radiosusceptibility. Our data suggest that genetic factors cause obvious variations in severity of damage after irradiation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 7th International Symposium on Predictive Oncology | |||||
| 発表年月日 | ||||||
| 日付 | 2004-02-10 | |||||
| 日付タイプ | Issued | |||||
