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マウス胎児の放射線適応応答誘導における線量率効果
https://repo.qst.go.jp/records/59936
https://repo.qst.go.jp/records/59936996a1756-1b0a-4d76-9220-19052a03e18f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-04 | |||||
| タイトル | ||||||
| タイトル | マウス胎児の放射線適応応答誘導における線量率効果 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
王, 冰
× 王, 冰× 王 冰 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radioadaptive response (AR) manifests an important phenomenon in radiobiology. Study of conditions essential for the induction of AR is of critical significance to understanding the novel biodefense mechanisms against the hazardous effects of irradiation. In our previous studies, the specific dose and timing of radiation for induction of AR was demonstrated in ICR mouse fetuses, namely, exposure of the fetuses on embryonic day 11 to a priming irradiation of 0.3 Gy significantly suppressed prenatal death and malformation induced by a challenging dose of irradiation on embryonic day 12. As a profound dose-rate effect has been observed in a variety of radiobiological phenomena, the dose-rate effect on the effectiveness of AR induction by a priming irradiation of 0.3 Gy administered to fetuses on embryonic day 11, was investigated in the range from 0.06 to 5.00 Gy/min. The occurrence of apoptosis in limb buds, incidences of prenatal death and digital defects, and postnatal mortality induced by a challenging dose of 3.5 Gy given at 1.80 Gy/min to the fetuses on embryonic day 12, were employed as biological endpoints. Unexpectedly, effective induction of AR was observed within two dose-rate ranges for the same dose of priming irradiation, namely, from 0.18 to 0.98 Gy/min and from 3.50 to 4.60 Gy/min, for reduction of the detrimental effect induced by a challenging dose of 3.5 Gy. Though neither a normal or reverse dose-rate effect was found, the results clearly indicated that the dose rate at which the priming irradiation was delivered played a crucial role in the induction of AR. This paper provides the first evidence for the existence of two dose-rate ranges for the same dose of priming irradiation to successfully induce AR in mouse fetuses. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成15年度第1回技術検討会 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-04-16 | |||||
| 日付タイプ | Issued | |||||
