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Intercomparison of Radiobiological RBE Among Japanese Proton Therapy Facilities
https://repo.qst.go.jp/records/59919
https://repo.qst.go.jp/records/59919af532f97-c123-431f-8a87-653c102460b1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-27 | |||||
| タイトル | ||||||
| タイトル | Intercomparison of Radiobiological RBE Among Japanese Proton Therapy Facilities | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furusawa, Yoshiya
× Furusawa, Yoshiya× Aoki, Mizuho× Shino, Yayoi× Lee, Ryonfa× Zhou, Guangming× Takai, Nobuhiko× Monobe, Manami× Fukawa, Takeshi× Miyato, Yasuyuki× Kagiya, Gou× 古澤 佳也× 青木 瑞穂× 志野 弥生× 周 光明× 高井 伸彦× 物部 真奈美× 扶川 武志× 宮戸 靖幸× 鍵谷 豪 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | INTRODUCTION HIMAC (Heavy-ion Medical Accelerator in Chiba) has constructed in 1993, and clinical trials has started in 1994 together with academic research activities, including physics, engineering, and biology. Pre-clinical radiobiological studies have performed to estimate clinical RBE for hadron beams. Following the HIMAC, several hadron therapy facilities (HIBMC, Hyogo; NCCHE, Kashiwa; WERC, Tsuruga; PMRC, Tsukuba; SCC, Shizuoka) have started the therapy in Japan. We have evaluated the RBE of each hadron beams for all the facilities with the same biological system and technical staffs as well as at HIMAC. METHODS Human salivary gland tumor cells (HSG) were used for the studies. All experiments were performed with single-dose exposures for both proton beams and linac X-rays at each facilities. All 60 mm SOBP beams were generated from 180-190 MeV proton beam, and the energy of high-energy linac X-rays were 4-6 MeV, but it depends on the facilities. Samples were placed at the plateau position or the entrance, middle, or proximal positions of SOBP beam or at the 50 mm depth position of the linac beam. The D10 values from survival curves by the colony formation assay were obtained. The RBE values of proton beams were calculated to X-ray data. RESULTS The average RBE at the middle of SOBP beam from all facilities was 1.030+/-0.017 (mean +/- SD). Flatness of the RBE in the SOBP were slightly disposed to increase with the depth. The values were slightly lower at the entrance, and little bit higher at the distal than that at the middle position. DISCUSSION X-ray data showed very good agreement and the deviations were less than 2 % among the facilities. The RBE values also showed good agreement among the facilities with 2 % or less standard deviation. Some difficulties were found in the irradiation systems, i.e. the dose determination and/or geometrical sample setting methods are different among the facilities. This may makes difficult exact comparative judgments of the radiobiological data. During the radiobiological experiments process, several problems were found and have solved. In this point of view, preclinical experiments were important as a simulation of patient treatments. CONCLUSION The RBE values for all proton therapy facilities in Japan were similar (1.02) with small deviation. The depth-dose distribution of all the SOBP beams has designed very well, and showed good uniformities of biological dose at all facilities. Physical dosimetry system should be unify for all the facilities to compare the results. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | WC2003 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-29 | |||||
| 日付タイプ | Issued | |||||
