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アイテム
Effects of Low Dose Particle Radiation to Mouse Premature Neurons in Culture
https://repo.qst.go.jp/records/59787
https://repo.qst.go.jp/records/59787039be851-dd17-425c-8197-bc01a10dc8a3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-06-03 | |||||
| タイトル | ||||||
| タイトル | Effects of Low Dose Particle Radiation to Mouse Premature Neurons in Culture | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nojima, Kumie
× Nojima, Kumie× Nagaoka, Shunji× 野島 久美恵× 長岡 俊治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of low dose heavy particle radiation to central nervous system (CNS) were studied using mouse neonatal brain cells in culture exposed to heavy ions and X ray at fifth days of the culture. The applied dose varied from 0.05Gy to 2.0Gy. The subsequent biological effects were evaluated by an induction of apoptosis and the survivability of neurons focusing on the dependencies of (1) the animal strains with different genetic types, and (2) LET of the different nucleons. Of the three mouse strains tested, SCID, B6 and C3H, for brain cell culture, SCID was the most sensitive and C3H the least sensitive to both X-ray and carbon ion (290MeV/n) when compared by 10 % apoptotic induction. However, the sensitivity differences among the strains were much smaller in case of carbon ion comparing to that of X-ray. The LET dependency was compared with using C3H and B6 cells exposing to different ions, proton (H, C, Ne, Ar, and Fe). Although no detectable LET dependency was observed at higher dose than 1 Gy, an enhancement was observed in the high LET (85 -200 KeV/_m) and low dose (<0.5 Gy) regions. The survivability profiles of the neurons were different in the mouse strains and ions. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th IAA Humans in Space Symposim | |||||
| 発表年月日 | ||||||
| 日付 | 2003-05-22 | |||||
| 日付タイプ | Issued | |||||
