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Initial Study of MET PET to Predict Response to Heavy-lon Radiotherapy in Patients with Muscleskeletal Malignant Tumors
https://repo.qst.go.jp/records/59781
https://repo.qst.go.jp/records/59781a19319ff-9b82-4d5f-a259-af97b11642c5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-05-23 | |||||
| タイトル | ||||||
| タイトル | Initial Study of MET PET to Predict Response to Heavy-lon Radiotherapy in Patients with Muscleskeletal Malignant Tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Hong
× Zhang, Hong× Yoshikawa, Kyosan× Tamura, Katsumi× Tomemori, Takashi× Suhara, Tetsuya× Suzuki, Kazutoshi× Tanada, Shuji× Murata, Hajime× Sasaki, Yasuhito× Tsujii, Hirohiko× 張 宏× 吉川 京燦× 田村 克巳× 留森 貴志× 須原 哲也× 鈴木 和年× 棚田 修二× 村田 啓× 佐々木 康人× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate whether positron emission tomography (PET) using 11C-methionine (MET) may early predict response to heavy-ion radiotherapy in patients with unresectable muscleskeletal malignant tumors. Thirty-five patients with 35 unresectable muscleskeletal malignant tumors were studied by MET PET at baseline and 11±4 days after completion of carbon radiotherapy. Clinical response ( reduction of tumor size by>50 parsent ) was evaluated after 6 months of therapy using standard imaging tecniques. The reduction of tumor MET uptale (mean±SD) after therapy was significantly different between responding (-49parsent ± 16parsent) and nonresponding tumors (-16parsent ± 13parsent). Optimal differentiation was achieved by a cutoff value of 30parsent resuction of initial MET uptake. Applying this cutoff value as a criterion for a metaabolic response predicted clinical response with a sensitivity and specificity of 94.1parsent (16of 17 patients) and 94.4parsent (17or 18 patients),respectively. The results of survival rate predicted by MET PET were consistent well with the clinical results. MET PET imaging may differentiate responding and nonresponding tumors early in the carbon ion radiotherapy in patients with muscleskeletal malignant tumors. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第42回日本核医学会総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2002-11-06 | |||||
| 日付タイプ | Issued | |||||
