WEKO3
アイテム
LET Dependent Hydroxyl Radical Generation in Water by Heavy-Ion Beam Irradiation
https://repo.qst.go.jp/records/58840
https://repo.qst.go.jp/records/588402da03ad0-fcdf-407b-b86b-4422ac2fdd8d
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-19 | |||||
| タイトル | ||||||
| タイトル | LET Dependent Hydroxyl Radical Generation in Water by Heavy-Ion Beam Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ogawa, Yukihiro
× Ogawa, Yukihiro× Sekine-Suzuki, Emiko× Nakanishi, Ikuo× Matsumoto, Ken-ichiro× 小川 幸大× 関根 絵美子× 中西 郁夫× 松本 謙一郎 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nano-geometry of hydroxyl radical (OH) generation in water caused by heavy-ion bream irradiation was evaluated using a fluorescent probe, disodium terephthalate (TPA-Na). Since OH is recognized as a primary product in biological effects of radiation, elimination of OH may be important to regulate the side effect of radiation therapy. Recently, using the electron paramagnetic resonance (EPR) spin-trapping technique, we reported that two different types of OH generations by ionizing radiation. In this study, linear energy transfer (LET) dependence on the density of localized OH generation was evaluated using TPA-Na. The irradiation of heavy-ion beams was performed at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, National Institute of Radiological Sciences, Japan). Several concentrations (0.5-208 mM) of TPA-Na in aqueous solutions were irradiated with 32 Gy of a heavy-ion beam (C400, Si490 or Ffe500) at several different LET. The amount of OH adduct of TPA-Na (hTPA) thus generated was measured by fluorophotometer (Ex. 310 nm/Em. 425 nm). The relationship between molecular density of TPA-Na and hTPA generated was analyzed. The amount of hTPA generated by low-LET heavy-ion beam was increased in proportion to the molecular density of TPA-Na and reached a plateau through an unclear inflection point. In the case of high-LET heavy-ion beam, however, another linear trend that passed through the origin was again observed when TPA-Na density was extremely high ([TPA-Na] = 156-208 mM). The linear increasing trend observed at high TPA-Na density suggests an extremely dense OH generation. | |||||
| 書誌情報 |
Free Radical Biology and Medicine 巻 112, 号 Suppl.1, p. 63, 発行日 2017-11 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.freeradbiomed.2017.10.088 | |||||
| 関連名称 | https://doi.org/10.1016/j.freeradbiomed.2017.10.088 | |||||
