WEKO3
アイテム
MR imaging techniques for nano-pathophysiology and theranostics
https://repo.qst.go.jp/records/58497
https://repo.qst.go.jp/records/58497a3d8d0be-592c-4d0d-81b6-f63b7d7dfd3e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-12-15 | |||||
| タイトル | ||||||
| タイトル | MR imaging techniques for nano-pathophysiology and theranostics | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
M., Bennett Kevin
× M., Bennett Kevin× Jo, Jun-ichiro× Cabral, Horacio× Bakalova-Zheleva, Rumiana× Aoki, Ichio× 城 潤一郎× バカロバ ルミアナ× 青木 伊知男 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The advent of nanoparticleDDSs (drug delivery systems, nano-DDSs) is opening newpathways to understanding physiology and pathophysiology at the nanometer scale. A nano-DDS can be used to deliver higher local concentrations of drugs to a target region andmagnify therapeutic effects.However, interstitial cells or fibrosis in intractable tumors, as occurs in pancreatic or scirrhous stomach cancer, tend to impede nanoparticle delivery. Thus, it is critical to optimize the type and size of nanoparticles to reach the target. High-resolution 3D imaging provides a means of “seeing” the nanoparticle distribution and therapeutic effects.We introduce the concept of “nano-pathophysiological imaging” as a strategy for theranostics. The strategy consists of selecting an appropriate nano-DDS and rapidly evaluating drug effects in vivo to guide the next round of therapy. In this articlewe classify nano-DDSs by component carrier materials and present an overview of the significance of nano-pathophysiological MRI. | |||||
| 書誌情報 |
Advanced Drug Delivery Reviews 巻 74, p. 75-94, 発行日 2014-04 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier B.V | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0169-409X | |||||
