WEKO3
アイテム
Redox-modulating and/or antioxidant properties of nitroxides – a potential reason for decreasing side-effects of cancer therapy
https://repo.qst.go.jp/records/58480
https://repo.qst.go.jp/records/58480567a27e5-45e6-46d1-8421-7d418aecb83a
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-21 | |||||
| タイトル | ||||||
| タイトル | Redox-modulating and/or antioxidant properties of nitroxides – a potential reason for decreasing side-effects of cancer therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ivanova, Donika
× Ivanova, Donika× Georgieva, Ekaterina× Lazarova, Desislava× Gadjeva, V.× Bakalova-Zheleva, Rumiana× Zhelev, Zhivko× イヴァノヴァ ドニカ× Ｇｅｏｒｇｉｅｖａ Ｅｋａｔｅｒｉｎａ× ラザロヴァ デシスラヴァ× バカロバ ルミアナ× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The existing therapeutic approaches – radiation therapy and conventional chemotherapy of cancer, suffer of serious side-effects as a result of increased generation of reactive oxygen and nitrogen species (ROS/RNS) in non-cancer cells and tissues. Currently, the development of oxidative stress in non-cancer tissues of cancer-bearing organism is a serious problem of cancer therapy. It is necessary to ask about a combination of substances expressing a therapeutic synergism as a result of differentiated effects on cancer and normal cells: substances with increased ROS/RNS-scavenging properties targeting normal cells and substances with increased ROS/RNS-generating properties targeting cancer cells. In this context, the redox-modulators are one of the most attractive candidates. The present review outlines the basic principle of this novel therapeutic strategy, focusing on nitroxide derivatives as one of the most promising redox-modulators with antioxidant ability. | |||||
| 書誌情報 |
Trakia Journal of Sciences 巻 3, 号 12, p. 329-337, 発行日 2014-10 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1313-3551 | |||||
