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The coat color genes regulate eumelanin and pheomelanin synthesis in melanocytes
https://repo.qst.go.jp/records/58084
https://repo.qst.go.jp/records/580841bbf3e4b-4dc7-4c39-9c5e-404def9bd0f9
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-06-01 | |||||
| タイトル | ||||||
| タイトル | The coat color genes regulate eumelanin and pheomelanin synthesis in melanocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In mice, eumelanin and pheomelanin synthesis is regulated by numerous coat color genes. Eumelanin and pheomelanin contents were measured in cultured melanocytes and in the epidermis/dermis and hairs of C57BL/10JHir (B10) and its congenic mice carrying the coat color genes. Eumelanin contents in agouti and dilute melanocytes are similar to black melanocytes, whereas the contents in brown, pink-eyed dilution, slaty and ruby-eye 2d melanocytes are reduced to one third~one thirthieth. In contrast, pheomelanin contents in agouti, dilute, slaty and ruby-eye 2d melanocytes are similar to its content in black melanocytes, whereas the content in brown melanocytes is increased. Eumelanin and pheomelanin contents in cultured epidermal melanocytes correlate well with those in skin and hair of the congenic mice, except that agouti melanocytes do not synthesize pheomelanin in culture, the pink-eyed dilution allele does not affect pheomelanin content in hairs, and the ruby-eye 2d allele increases pheomelanin content in hairs. These results suggest that eumelanin and pheomelanin synthesis in melanocytes is regulated by numerous coat color genes in a complicated manner. | |||||
| 書誌情報 |
Melanin : Biosynthesis, Functions and Health Effects p. 109-137, 発行日 2012-05 |
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| 出版者 | ||||||
| 出版者 | Nova Science | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-1-6210-0991 | |||||
