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The bystander response to heavy-ion radiation: intercellular signaling between irradiated and non-irradiated cells
https://repo.qst.go.jp/records/57790
https://repo.qst.go.jp/records/5779058e827b6-1d98-4f28-9ab8-98ed758fac31
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-22 | |||||
| タイトル | ||||||
| タイトル | The bystander response to heavy-ion radiation: intercellular signaling between irradiated and non-irradiated cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hamada, Nobuyuki
× Hamada, Nobuyuki× 浜田 信行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ionizing radiation-induced bystander effect is the phenomenon whereby cells that are not themselves irradiated but received signals from directly irradiated cells exhibit biological responses. Human exposure to heavyion radiation occurs during manned space missions at the dose and dose rate much lower than those for cancer therapy. It should be noted herein that less irradiated cells coexist with more non-irradiated counterparts in a cell population exposed to a lower dose of radiation whose linear energy transfer is higher. The bystander effect should be thence examined to decipher the action mechanism of low-dose heavy ions. The bystander effect of heavy ions is manifested as inactivated clonogenic potential, a transient apoptotic response, delayed p53 phosphorylation, gene expression changes, a transient cell-cycle arrest, chromosome aberrations, elevated mutation frequency and micronucleation. Proposed underpinning mechanisms involve gap junctional intercellular communication and reactive oxygen/nitrogen species. This paper reviews briefly the current knowledge of the heavy ion-induced bystander effect. |
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| 書誌情報 |
Biological Sciences in Space 巻 23, 号 4, p. 195-201, 発行日 2009 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9201 | |||||
