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Highly valiable structure of the ubiquitin gene: Implication in the stress management of the eukaryotes.
https://repo.qst.go.jp/records/56530
https://repo.qst.go.jp/records/5653007bea83d-74a2-403e-91cb-4179fa72f805
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-14 | |||||
| タイトル | ||||||
| タイトル | Highly valiable structure of the ubiquitin gene: Implication in the stress management of the eukaryotes. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nenoi, Mitsuru
× Nenoi, Mitsuru× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ubiquitin is a highly conserved small protein participating in a large number of biological processes as a tag in the selective proteolysis of short-lived regulatory proteins, as well as abnormal or foreign proteins via the so-called ubiquitin system. There is evidence that the roles played by ubiquitin are closely related to cellular stress responses; namely, that numerous factors involved in cellular stress management, such as p21waf1/Cip1, p53, Gadd45, BRCA1, and NF- B, are substrates of the ubiquitin system. Ubiquitin genes are transcriptionally induced by a wide range of stresses although the range of stresses to which ubiquitin genes respond has not been conserved among species. In humans, ubiquitin is encoded by UbA52, UbA80, UbB and UbC. The UbB and UbC genes are termed polyubiquitin genes because they encode tandemly repeated multiple ubiquitins with no intervening spacer. All polyubiquitin genes of mammals investigated could be classified into two orthologous gene groups, UbB-type and UbC-type, based on the sequence homology in the 3 UTR. In contrast to the highly conserved amino acid sequence, the structure of the ubiquitin-coding genes is considered to be highly variable. Thus we consistently found a greater degree of homology between ubiquitin-coding units within a polyubiquitin gene than in orthologous repeat units in different species. This means that concerted evolution has occurred in all polyubiquitin genes investigated. Postulating that the major mechanism of concerted evolution in polyubiquitin genes is unequal crossing over, we estimated through numerical simulation the frequency of concerted evolutionary events in human UbC at no more than 5.0x10-7 per year, and of the human UbB at 3.3x10-7 per year. Moreover it was revealed that concerted evolutionary events in polyubiquitin genes have been more frequent in rats and Chinese hamsters than in humans, cow and sheep. The Guinea pig polyubiquitin gene was an intermediate example. It can be considered that variability of the polyubiquitin gene structure would be a result of the adaptation of species to dynamically changing environmental stress. | |||||
| 書誌情報 |
Recent Research Developments in Genetics 巻 2, p. 121-131, 発行日 2002 |
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| 出版者 | ||||||
| 出版者 | Research Signpost | |||||
