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Regulation of catalase gene transcription by ionizing radiation: a possible mechanism for radiation-induced apoptosis
https://repo.qst.go.jp/records/56529
https://repo.qst.go.jp/records/565293943690b-2d42-46df-91bf-c1cbac14490e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-14 | |||||
| タイトル | ||||||
| タイトル | Regulation of catalase gene transcription by ionizing radiation: a possible mechanism for radiation-induced apoptosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nenoi, Mitsuru
× Nenoi, Mitsuru× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Catalase has been thought to play a central role in the protection of cells against oxidative stress by converting H2O2 to O2 and H2O. However, in some cases, catalase of mammals is down-regulated by H2O2, as well as by ionizing radiation and lipopolysaccharides, the cytotoxic effects of both of which are mediated by the production of H2O2. In addition, it has been estimated that glutathione peroxidase is responsible for 91% of H2O2 consumption in cytosol, whereas catalase is responsible only for a minor part. Because a large body of evidence has revealed that H2O2 regulates signal transduction in the apoptotic process, it may be hypothesized that the predominant role of catalase in mammals is not to protect cells against H2O2, but to regulate apoptosis in response to death-promoting stimuli, including ionizing radiation, by controlling cellular H2O2 levels. | |||||
| 書誌情報 |
Research Advances in Cancer p. 131-138, 発行日 2002 |
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| 出版者 | ||||||
| 出版者 | Global Reaearch Network | |||||
