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消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響(12J371)
https://repo.qst.go.jp/records/56147
https://repo.qst.go.jp/records/56147b690fd33-0255-4210-829d-2401b5ff76b5
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響(12J371) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 崔 星× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate whether a carbon ion beam in combination with gemcitabine has advantages over X-ray in targeting putative pancreatic cancer stem-like cells (CSCs) in vitro and in vivo. The number of colonies and spheroids formed from CSCs after carbon ion beam was significantly reduced compared to after X-ray irradiation, and they were extremely highly suppressed when carbon ion beam combined with gemcitabine. Expressions of multiple cell death-related genes were remarkably highly induced, and large numbers of H2AX foci in CSCs were formed after carbon ion beam combined with gemcitabine. The highly expressed CSC markers were significantly inhibited after 30 Gy of carbon ion beam and almost lost after 25 Gy carbon ion beam combined with 50 mg/kg gemcitabine. In conclusion, a carbon ion beam combined with gemcitabine has superior potential to kill pancreatic CSCs via irreparable clustered DSB compared to a carbon ion alone or X-rays combined with gemcitabine | |||||
| 書誌情報 |
平成26年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2015-02 |
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