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重粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103a)
https://repo.qst.go.jp/records/56146
https://repo.qst.go.jp/records/5614698ff688c-926e-4c11-b59d-b999b19b3f1f
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 重粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103a) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 中島, 菜花子× 鈴木, 雅雄× 崔 星× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 中島 菜花子× 鈴木 雅雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate whether a carbon ion beam alone or in combination with cisplatin (CDDP) has beneficial effects compared to X-ray, the triple negative (TN) breast cancer stem cells (CSCs), sorted from MDA MB231 cells were treated with carbon ion beam or X-ray irradiation alone or in combination with CDDP. The colony, spheroid formation and tumorigenicity assays showed that CD44+/CD24- cells exactly have CSC properties compared to CD44-/CD24- and CD44-/CD24+ cells. Carbon ion beam combined with CDDP significantly suppressed colony and spheroid formation compared to that of X-ray combined with CDDP as well as carbon ion alone. RT-PCR Array analysis showed that expression of DNA repair, apoptosis and autophagy related genes were differently altered between carbon ion beam and X-ray irradiation alone or in combination with CDDP, and carbon ion beam combined with CDDP more highly induced apoptosis and autophagy compared to X-ray combined with CDDP. Immunofluorescence assay showed that not only the number but also the size of H2AX foci in CSCs were lager 24 h after carbon ion beam combined with CDDP compared to that of X-ray combined with CDDP as well as carbon ion alone. Taken together, carbon ion beam combined with CDDP has superior potential to kill TN breast CSCs with unrepairable severe DNA damage and enhanced apoptosis as well as autophagy. | |||||
| 書誌情報 |
平成27年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2016-02 |
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