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重粒子治療適応拡大に向けた薬物併用療法の基礎的研究(J103)
https://repo.qst.go.jp/records/56141
https://repo.qst.go.jp/records/561418ea96c37-33ae-4381-8d52-9d978161d23e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 重粒子治療適応拡大に向けた薬物併用療法の基礎的研究(J103) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× Woong Seop, Keum× 滝澤, 和也× 鈴木, 雅雄× 藤森, 亮× 山田, 滋× 鎌田, 正× Sai, Sei× Keum, WoongSeop× Takizawa, Kazuya× Suzuki, Masao× Fujimori, Akira× Yamada, Shigeru× Kamada, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Colorectal cancer (CRC) is a typical gastrointestinal cancer. In this study we investigated how effective on killing CRC cells by carbon ion beam alone or in combination with 5-fluorouracil (5-FU) in vitro. Carbon ion beam dose-independently suppressed HCT116 and HT29 cell viability and in combination with 5-FU (5M) significantly enhanced its action. Spheroid formation ability of cancer stem like CD133+ cells was significantly inhibited by carbon ion beam combined with 5-FU in HCT116 cells. Apoptosis analysis showed that the percentage of apoptotic cells was increased after carbon ion beam alone with 3Gy and it was extremely increased when combined with 5-FU. Quantitative real time PCR analysis showed that expression of apoptosis-related BAX and autophagy-related ATG7 was significantly enhanced by carbon ion beam alone, and in combination with 5-FU significantly further enhanced expression of those genes compared to carbon ion beam, 5-FU alone. In conclusion, carbon ion beam combined with 5-FU has superior potential to kill CRC cells including CSCs with enhanced apoptosis | |||||
| 書誌情報 |
平成29年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書, 発行日 2018-02 |
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