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  1. 研究・技術・調査報告

重粒子治療適応拡大に向けた薬物併用療法の基礎的研究(J103)

https://repo.qst.go.jp/records/56141
https://repo.qst.go.jp/records/56141
8ea96c37-33ae-4381-8d52-9d978161d23e
Item type 一般雑誌記事 / Article(1)
公開日 2019-02-12
タイトル
タイトル 重粒子治療適応拡大に向けた薬物併用療法の基礎的研究(J103)
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 崔, 星

× 崔, 星

WEKO 751543

崔, 星

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Woong Seop, Keum

× Woong Seop, Keum

WEKO 751544

Woong Seop, Keum

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滝澤, 和也

× 滝澤, 和也

WEKO 751545

滝澤, 和也

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鈴木, 雅雄

× 鈴木, 雅雄

WEKO 751546

鈴木, 雅雄

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藤森, 亮

× 藤森, 亮

WEKO 751547

藤森, 亮

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山田, 滋

× 山田, 滋

WEKO 751548

山田, 滋

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鎌田, 正

× 鎌田, 正

WEKO 751549

鎌田, 正

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Sai, Sei

× Sai, Sei

WEKO 751550

en Sai, Sei

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Keum, WoongSeop

× Keum, WoongSeop

WEKO 751551

en Keum, WoongSeop

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Takizawa, Kazuya

× Takizawa, Kazuya

WEKO 751552

en Takizawa, Kazuya

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Suzuki, Masao

× Suzuki, Masao

WEKO 751553

en Suzuki, Masao

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Fujimori, Akira

× Fujimori, Akira

WEKO 751554

en Fujimori, Akira

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Yamada, Shigeru

× Yamada, Shigeru

WEKO 751555

en Yamada, Shigeru

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Kamada, Tadashi

× Kamada, Tadashi

WEKO 751556

en Kamada, Tadashi

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抄録
内容記述タイプ Abstract
内容記述 Colorectal cancer (CRC) is a typical gastrointestinal cancer. In this study we investigated how effective on killing CRC cells by carbon ion beam alone or in combination with 5-fluorouracil (5-FU) in vitro. Carbon ion beam dose-independently suppressed HCT116 and HT29 cell viability and in combination with 5-FU (5M) significantly enhanced its action. Spheroid formation ability of cancer stem like CD133+ cells was significantly inhibited by carbon ion beam combined with 5-FU in HCT116 cells. Apoptosis analysis showed that the percentage of apoptotic cells was increased after carbon ion beam alone with 3Gy and it was extremely increased when combined with 5-FU. Quantitative real time PCR analysis showed that expression of apoptosis-related BAX and autophagy-related ATG7 was significantly enhanced by carbon ion beam alone, and in combination with 5-FU significantly further enhanced expression of those genes compared to carbon ion beam, 5-FU alone. In conclusion, carbon ion beam combined with 5-FU has superior potential to kill CRC cells including CSCs with enhanced apoptosis
書誌情報 平成29年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書,

発行日 2018-02
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