{"_buckets": {"deposit": "af81ce54-eeb3-44d0-a644-f695fb9f2d48"}, "_deposit": {"created_by": 1, "id": "56140", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "56140"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00056140", "sets": ["7"]}, "author_link": ["574306", "574307", "574305", "574298", "574303", "574304", "574302", "574300", "574299", "574301"], "item_10004_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-02", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{"bibliographic_title": "平成29年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書"}]}]}, "item_10004_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Malignant mesothelioma (MM) is extremely aggressive and a typical refractory cancer. In this study we investigated how effective on control MM xenograft tumor by carbon ion beam alone or in combination with cisplatin (CDDP) in vivo. We found that MESO1 xenograft tumor growth is slow (12 weeks after injection of the cells the tumors reach around 10 mm), whereas H226 xenograft tumor growth is relatively fast (4 weeks after injection of the cells the tumors reach around 10 mm). Thus we used H226 xenograft in this study. Carbon ion beam irradiation with 15Gy effectively suppressed H226 xenograft tumor volume and in combination with CDDP (5.0mg/kg ip) significantly enhanced its action. Carbon ion beam alone with high dose (25Gy) significantly reduced tumor volume but CDDP (5mg/kg ip) alone did not. Histopathological analysis showed that carbon ion beam with 25 Gy significantly induced tumor cell fibrosis, cavitation and necrosis compared to that of irradiated by carbon ion beam with 15 Gy or CDDP alone. The analysis of combination treatment of carbon ion beam and CDDP is undergoing. In conclusion, high dose of carbon ion beams or relatively low dose of carbon ion beam combined with CDDP has superior potential to control MM xenograft tumor.", "subitem_description_type": "Abstract"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "崔, 星"}], "nameIdentifiers": [{"nameIdentifier": "574298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 泰寿"}], "nameIdentifiers": [{"nameIdentifier": "574299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平川, 博一"}], "nameIdentifiers": [{"nameIdentifier": "574300", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 雅雄"}], "nameIdentifiers": [{"nameIdentifier": "574301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤森, 亮"}], "nameIdentifiers": [{"nameIdentifier": "574302", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "崔 星", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "574303", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田 泰寿", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "574304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平川 博一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "574305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 雅雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "574306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤森 亮", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "574307", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "移植腫瘍モデルを用いた重粒子線治療適応拡大のための基礎研究(J123)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "移植腫瘍モデルを用いた重粒子線治療適応拡大のための基礎研究(J123)"}]}, "item_type_id": "10004", "owner": "1", "path": ["7"], "permalink_uri": "https://repo.qst.go.jp/records/56140", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-02-12"}, "publish_date": "2019-02-12", "publish_status": "0", "recid": "56140", "relation": {}, "relation_version_is_last": true, "title": ["移植腫瘍モデルを用いた重粒子線治療適応拡大のための基礎研究(J123)"], "weko_shared_id": -1}