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移植腫瘍モデルを用いた重粒子線治療適応拡大のための基礎研究(J123)
https://repo.qst.go.jp/records/56140
https://repo.qst.go.jp/records/561400c4eba78-d930-48e1-977a-892378b21c35
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 移植腫瘍モデルを用いた重粒子線治療適応拡大のための基礎研究(J123) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 山田, 泰寿× 平川, 博一× 鈴木, 雅雄× 藤森, 亮× 崔 星× 山田 泰寿× 平川 博一× 鈴木 雅雄× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Malignant mesothelioma (MM) is extremely aggressive and a typical refractory cancer. In this study we investigated how effective on control MM xenograft tumor by carbon ion beam alone or in combination with cisplatin (CDDP) in vivo. We found that MESO1 xenograft tumor growth is slow (12 weeks after injection of the cells the tumors reach around 10 mm), whereas H226 xenograft tumor growth is relatively fast (4 weeks after injection of the cells the tumors reach around 10 mm). Thus we used H226 xenograft in this study. Carbon ion beam irradiation with 15Gy effectively suppressed H226 xenograft tumor volume and in combination with CDDP (5.0mg/kg ip) significantly enhanced its action. Carbon ion beam alone with high dose (25Gy) significantly reduced tumor volume but CDDP (5mg/kg ip) alone did not. Histopathological analysis showed that carbon ion beam with 25 Gy significantly induced tumor cell fibrosis, cavitation and necrosis compared to that of irradiated by carbon ion beam with 15 Gy or CDDP alone. The analysis of combination treatment of carbon ion beam and CDDP is undergoing. In conclusion, high dose of carbon ion beams or relatively low dose of carbon ion beam combined with CDDP has superior potential to control MM xenograft tumor. | |||||
| 書誌情報 |
平成29年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2018-02 |
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