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The Importance of Primary and Secondary Bystander Response Crosstalk between Human Lung Cancer and Normal Cells by Exposure of High-LET Carbon Ions (16J318)
https://repo.qst.go.jp/records/56067
https://repo.qst.go.jp/records/560675d7a4a9f-04e9-4b33-b530-07b5f2cc7893
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-15 | |||||
| タイトル | ||||||
| タイトル | The Importance of Primary and Secondary Bystander Response Crosstalk between Human Lung Cancer and Normal Cells by Exposure of High-LET Carbon Ions (16J318) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Autsavapromporn, Narongchai
× Autsavapromporn, Narongchai× Kobayashi, Alisa× Liu, Cuihua× Furusawa, Yoshiya× Konishi, Teruaki× 小林 亜利紗× 劉 翠華× 古澤 佳也× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiotherapy is the most commonly used treatments for cancer, particularly for heavy ions such as carbon ions. However, the mechanism underlying the primary- and secondary bystander response between irradiated cancer cells and neighboring normal cells are poorly understood. Using the layers tissue culture model to investigate the primary- and secondary bystander responses crosstalk between carbon-irradiated A549 cells and bystander normal WI-38 cells. Preliminary findings show that primary- and secondary bystander cells that had been co-cultured with carbon-irradiated A549 cells exhibited increased micronucleus (MN) formation compared to respective control. In contrast, treatment with NO inhibitor shows a decrease of MN formation in primary bystander cells but not in secondary bystander cells. These results show that NO play a key role on the primary and secondary bystander response. |
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| 書誌情報 |
平成28 年度放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書 巻 2016, 号 HIMAC-145, p. 92-93, 発行日 2017-11 |
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