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Cell death bypass mechanisms in DNA damage response of mammalian cells after exposure with heavy ions relevant for Space radiation environment (13J399)
https://repo.qst.go.jp/records/55976
https://repo.qst.go.jp/records/55976f3133bc2-fcbb-4aaf-89e3-899b8114c46b
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-20 | |||||
| タイトル | ||||||
| タイトル | Cell death bypass mechanisms in DNA damage response of mammalian cells after exposure with heavy ions relevant for Space radiation environment (13J399) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
F, Spitta Luis
× F, Spitta Luis× Baumstark-Khan, Christa× Diegeler, Sebastian× Feles, Sebastian× E, Hellweg Christene× Henschenmacher, Bernd× Konishi, Teruaki× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For humans in space, there are two limiting factors namely the microgravity and the galactic cosmic radiation. For sake of better risk assessment for the astronaut, the cellular response to such ionizing radiation qualities, as predominate in Space, needs to be better understood. One of the key elements to be investigated is the cell cycle control as a central element in DNA damage response being a central switch for cellular decision making between life and death. Thus cell death bypass mechanisms in DNA damage response of mammalian cells will be investigated after heavy ion exposure relevant for the Space radiation environment. The RBE-LET dependency will be determined for different biological endpoints. Of special interest are cellular survival, the activation of transcription factors and the identification of genes expressed in DNA damage response after high LET exposure. | |||||
| 書誌情報 |
平成26 年度放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書 巻 HIMAC-143, p. 115-116, 発行日 2016-03 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
