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重粒子線照射による肺晩発障害機構の解明
https://repo.qst.go.jp/records/55878
https://repo.qst.go.jp/records/558789de0b006-b1ad-4297-b863-1a37d0fa4e05
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-10 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射による肺晩発障害機構の解明 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
下川, 卓志
× 下川, 卓志× 藤田, 英俊× 安藤, 謙× 松本, 謙一郎× 中渡, 美也子× 森竹, 浩之× 佐藤, 克俊× 中村, 悦子× 今井, 高志× 下川 卓志× 藤田 英俊× 安藤 謙× 松本 謙一郎× 中渡 美也子× 森竹 浩之× 佐藤 克俊× 中村 悦子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced pneumonitis and consequential pulmonary fibrosis are known serious side effects after thoracic radiation therapy. Since these side effects act as a dose-limiting factor, understanding the molecular and pathogenic mechanisms underlying these symptoms is essential for improvement of radiotherapy, including heavy ion radiotherapy. In this study, we aim to identify molecular mechanisms, which can become novel target for prevention or treatment of radiation induced pneumonitis and pulmonary fibrosis. C3H/He, C57BL/6J and C3B6F1 mice were locally irradiated in the thorax by carbon-ion beam (290MeV/n), and subsequently we performed histological analyses of the lung at different time points after irradiation. Previously our study showed pneumonitis and consequential pulmonary fibrosis developed 5-6 months after irradiation. Due to the fact that less than 5 months have passed since our first dose of radiation (2011.9.27), we are currently observing the pathological changes. We will report our results next year. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-251, 号 HIMAC-138, p. 72-73, 発行日 2012-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
