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重粒子線により誘導されるバイスタンダー応答および適応応答へのNOラジカルの関与
https://repo.qst.go.jp/records/55836
https://repo.qst.go.jp/records/5583635866ed9-6226-42bb-9b9a-4879d8ab6865
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-31 | |||||
| タイトル | ||||||
| タイトル | 重粒子線により誘導されるバイスタンダー応答および適応応答へのNOラジカルの関与 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
松本, 英樹
× 松本, 英樹× 大塚, 健介× 畑下, 昌範× 古澤, 佳也× ヘイ, トム× 浜田, 信行× 柿沼, 志津子× 内堀, 幸夫× その他× 松本 英樹× 大塚 健介× 古澤 佳也× 浜田 信行× 柿沼 志津子× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE To investigate whether radioadaptive responses were induced after irradiation with accelerated ion beams through nitric oxide-mediated bystander response in cultured cells in vitro and in some organs of mice in vivo. MATERIALS AND METHODS (1)Human non-small cell lung carcinoma cells transfected with wild-type p53 (H1299/wtp53 cells) were used. The cells were irradiated with accelerated carbon ion beams (290 MeV/u, 31 keV/µm or 135 MeV/u, 31 keV/µm). Then, the cells were allowed forming colonies. (2)ICR male mice (Jcl:ICR) were used. The mice were irradiated on 2 days with accelerated carbon ion beams (290 MeV/u, 13 keV/µm or 135 MeV/u, 25 keV/µm) or argon ion beams (500 MeV/u, 90 keV/µm). The small intestine and testis were excised 2 days after the last irradiation. These excised tissues were fixed, embedded in paraffin and made of thin-sections on slide glasses. Then the TUNEL- and activated caspase-3-positive cells in the thin-sections of tissues were detected by the immunohistochemical method. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 p. 000, 発行日 2011-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
