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Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role?
https://repo.qst.go.jp/records/55806
https://repo.qst.go.jp/records/55806a9cd25c0-2422-46ed-9a72-dbaeed4dbd57
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-18 | |||||
| タイトル | ||||||
| タイトル | Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Zhenhua
× Wang, Zhenhua× Hong, Zhang× Bing, Wang× Tanaka, Kaoru× Zhou, Xin× Liu, Yang× Gan, Lu× Sun, Chao× Ｗａｎｇ Ｚｈｅｎｈｕａ× Ｈｏｎｇ Ｚｈａｎｇ× 王 冰× 田中 薫× Ｌｉｕ Ｙａｎｇ× Ｇａｎ Ｌｕ× Ｓｕｎ Ｃｈａｏ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced brain injury (RBI) is the most serious adverse reaction in cranial radiotherapy, which will cause the loss of neurons and cerebral capillary and finally result in the cognitive impairment. As the power house of cells, mitochondria play the essential role in keeping the stabilization of brain energy metabolism. However, the mitochondrial DNA (mtDNA) is a vulnerable target of irradiation, the injury of mtDNA might be the root of RBI. Here we investigted the mtDNA injury and the cerebral ischemia induced by carbon ions or X-rays. The long PCR results indicated that both carbon ions and X-rays caused the mtDNA injury and upregulated the expression of HIF-1arufa. The mtDNA injury and expression of HIF-1arufa maintained in high level in carbon ions irradiated group, whereas they recovered to the control level in X-rays irradiated group which indicated that the injury induced by carbon ions is more difficult to repair in brain tissue. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 HIMAC-138, p. 68-69, 発行日 2012-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
