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Does Radioadaptive Response Also Apply to the Case of Heavy-ion Irradiations in Fetal and Adult Mice?
https://repo.qst.go.jp/records/55805
https://repo.qst.go.jp/records/5580584e07e19-3428-4975-841d-b592cd2efa73
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-18 | |||||
| タイトル | ||||||
| タイトル | Does Radioadaptive Response Also Apply to the Case of Heavy-ion Irradiations in Fetal and Adult Mice? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Maruyama, Kouichi× Vares, Guillaume× Fujita, Kazuko× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× 王 冰× 田中 薫× 二宮 康晴× 丸山 耕一× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 藤田 和子× 笠井 清美× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Induction of adaptive response (AR) by the high LET accelerated heavy ion irradiations (HI) is being attempted both in young adult female mice and in fetal mice of C57BL/6J strain, using mainly thirty-day survival in vivo and prenatal death & malformation in utero as endpoints. In fiscal year 2011, using carbon, silicon, neon, and iron HI and X-rays, we demonstrated that 1) in the in utero studies, the priming low dose neon-ion irradiations could not induce any protective effects against the detrimental effects from the challenging irradiations from X-rays; 2) in the in vivo studies, no AR was observable in the following combinations for the priming and challenging irradiations: silicon plus carbon, iron plus carbon, and iron plus silicon. Thus we have finished all the radiation combinations in the in utero studies. The findings in the in utero studies indicate that induction of AR by X-rays against high LET HI is an event depending on the LET or/and species of the ions, and it seems hardly to induce AR by high LET HI against X-rays. For the in vivo studies, most radiation combinations are finished or under investigation, and we expect to complete the remaining combination in the fiscal year 2012. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 HIMAC-138, p. 52-53, 発行日 2012-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
