WEKO3
アイテム
動物実験のヒトへの外挿可能性について
https://repo.qst.go.jp/records/55706
https://repo.qst.go.jp/records/55706e5710195-9ed3-4fae-9722-025b721a4cbc
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-15 | |||||
| タイトル | ||||||
| タイトル | 動物実験のヒトへの外挿可能性について | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
齊尾, 武郎
× 齊尾, 武郎× 栗原, 千絵子× 栗原 千絵子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background:Today, thousands of animal experimentations are performed to develop innovative drugs.But the validity of animal experiments is in question from the view point of their scientific value and ethicalconsideration. Methods:A non-systematic review of the literature concerning the concordance of the results betweenanimal experiments and clinical trials. Also we critically evaluated the famous Olson study on theconcordance of the toxicity of pharmaceuticals between humans and in animals written in the year 2000. Results:There is a discordance of results between animal experiments and clinical trials because of 1)scientifically questionable methods either in animal experiments or clinical trials, 2) rather irrelevantanimal models to human diseases, and 3) existence of publication bias. Though the Olson study shows theproportion of concordance of human toxicity from animals as a "true positive concordance rate"(actually,"sensitivity"), this epidemiological measure is not predictive of human toxicity unlike positive predictivevalue (PPV). Conclusions:Scarce evidence exists supporting the extrapolation of results of animal experiments totreatment or prevention of diseases in humans. The Olson study does not demonstrate the predictabilityfrom animal experiments to human toxicities of drugs contrary to the widespread acceptance of theusefulness of animal experiments in the development of new drugs. |
|||||
| 書誌情報 |
臨床評価 巻 38, 号 2, p. 385-392, 発行日 2010 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0300-3051 | |||||
