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重粒子線照射によるゲノム構造と遺伝子発現量の変化（20B485)
https://repo.qst.go.jp/records/55687
https://repo.qst.go.jp/records/556877799c00d-f8a9-4574-a450-571f6273e9a6
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-26 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射によるゲノム構造と遺伝子発現量の変化（20B485) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
道川, 祐市
× 道川, 祐市× 石川, 顕一× 藤田, 真由美× 盛武, 敬× 岩川, 眞由美× 道川 祐市× 石川 顕一× 藤田 真由美× 盛武 敬× 岩川 眞由美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim of this study is to understand cellular and molecular nature of cancer cells survived for long term after charged particle exposure. During the period of 1st year, clonogenic sensitivity of various cancer cell lines against charged particles was investigated by two experimental strategies. Firstly, mouse cancer cell line analysis in the presence of 5-azacytidine, a DNA methylation inhibitor, revealed epigenetic heterogeneity of charged particle sensitivity within the cell population. In the second approach, human glioblastoma cell line, Becker, was investigated for the phenotypic changes after long term survival period (3 weeks). Especially, the cells were revealed to be sensitized toward secondary exposure of charged particles in a way of primary dose-dependence. However, this tendency was clearly eliminated when cells were treated by 5-azacytidine before the primary exposure. Thus, epigenetic regulations of cellular genomic DNA were also supposed to play important roles in the radiation sensitivity changes of the long-term survived cells. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2009, p. 163-164, 発行日 2009-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
