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粒子線治療の腫瘍治療効果と障害に関する研究（18B157)
https://repo.qst.go.jp/records/55676
https://repo.qst.go.jp/records/55676e7e02d1d-d461-47da-a6ed-10b74b20de82
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-01-28 | |||||
| タイトル | ||||||
| タイトル | 粒子線治療の腫瘍治療効果と障害に関する研究（18B157) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鵜澤, 玲子
× 鵜澤, 玲子× 安藤, 興一× 古澤, 佳也× 小池, 幸子× 平山, 亮一× 松本, 孔貴× 松藤, 成弘× 鵜澤 玲子× 安藤 興一× 古澤 佳也× 小池 幸子× 平山 亮一× 松本 孔貴× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Feet of mice were locally irradiated with mono-peak carbon ions (290 MeV/u). Single doses and daily fractionation up to 6 fractions were used. Isoeffect doses were plotted against number of fractions for carbon ions. A linear regression line well fit to gamma-ray data in Fe-plot. However, this linearlity was gradually lost with an increase of LET so that reciprocal isoeffect doses did not increase between single and 2 fractions for 58 keV/mm carbon ions. This means that sensitivity of skin cells for high LET carbon ions is different between single and fractionated doses. Significance of heterogeneous populations within a tumor in carbon therapy was experimentally studied. Tumor cell suspensions that contained various ratios of two fibrosarcomas with different g-ray sensitivities were transplanted into syngeneic C3H mice. The transplanted tumors were irradiated after single doses of 74 keV/mm carbon beams, and tumor growth delay and tumor control probabilities were measured. Presence of a radiosensitive subpopulation affected growth delay of irradiated tumors, but did not contribute to tumor controls after carbon-ion irradiation. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2009, p. 35-36, 発行日 2009-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
