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マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析
https://repo.qst.go.jp/records/55621
https://repo.qst.go.jp/records/55621ad053c1e-7301-4853-810b-bb7ef8930c6c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-03 | |||||
| タイトル | ||||||
| タイトル | マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岩川, 眞由美
× 岩川, 眞由美× 盛武, 敬× 野尻, 和典× 田巻, 倫明× 酒井, 美奈子× 今井, 高志× 岩川 眞由美× 盛武 敬× 野尻 和典× 田巻 倫明× 酒井 美奈子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To identify molecular mechanism of effectiveness induced by carbon-ion radiotherapy, we investigated expression profiles of murine tumors, which varied its radiosensitivity to gamma irradiation, using microarrays consisting of 55K genes. Six murine tumors (squamous cell carcinoma: NR-S1, SCCVII, Fibrosarcoma: NFSa, #8520, and Mammary carcinoma: MCa#4, MMCa) were transplanted in hind legs of C3H/Henirs mice and solid tumors were irradiated with either carbon-ion beam or gamma-ray. In microarray analysis, the pairwise comparisons between pre-treatment sample and post- treatment sample at 6h, 1 day, and 3 day after irradiation in each tumor were made by Wilcoxon test. We detected several tens of genes, whose expressions were significantly changed after carbon-irradiation. These genes were ontologically categorized into cell-cycle and immune response. Furthermore, comparison of expression intensity between radiosensitive (SCC-VII) and radioresistant (NR- S1) tumors by ANOVA test revealed a candidate molecule to be related with radioresistance. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-214, 号 HAIMAC-129, p. 108-109, 発行日 2008-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
