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神経膠腫細胞の重粒子線照射効果関連レドックス遺伝子群の解析
https://repo.qst.go.jp/records/55620
https://repo.qst.go.jp/records/55620d2e6b412-5234-4774-a136-99f86ed6d26a
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-03 | |||||
| タイトル | ||||||
| タイトル | 神経膠腫細胞の重粒子線照射効果関連レドックス遺伝子群の解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
盛武, 敬
× 盛武, 敬× 田草川, 光子× 中渡, 美也子× 今留, 香織× 酒井, 美奈子× 中村, 悦子× 柳澤, 充× 安西, 和紀× 岩川, 眞由美× 今井, 高志× 盛武 敬× 田草川 光子× 中渡 美也子× 今留 香織× 酒井 美奈子× 中村 悦子× 柳澤 充× 安西 和紀× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose --- In order to clarify the molecular changes in response to high LET carbon ion irradiation in human glioblastoma cell lines. Materials and methods --- For evaluating the cell survival to X-ray and Carbon ion beams, colony-formation assays were performed in 11 glioblastoma and 2 fibroblast cell lines. In addition, 1.0 uM of 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) , which is rather stable radical, was added to MEM suspended with 7.5x106 cells/ml of each cells. Then, the decay of its electron spin resonance (ESR) was measured during 120 min using ESR spectrometer. Also, to elucidate the molecular response to irradiation, the total RNA was purified from those cells at 1 h, 3 h and 24 h after 2 Gy of exposure with X-ray and carbon ion beams. Results --- The sensitivity to X-ray varied widely in 11 glioblastoma cell lines. On the other hand, the survival curves for carbon ion irradiation showed little difference in sensitivity among them. The decay rates of Tempol signal were also varied among cell limes. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-214, 号 HAIMAC-129, p. 124-125, 発行日 2008-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
